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Evaluation of the a...
Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma
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- Liu, Zhiwei (författare)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA.
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- Jarrett, Ruth F. (författare)
- Univ Glasgow, MRC, Ctr Virus Res, Glasgow, Lanark, Scotland.
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- Hjalgrim, Henrik (författare)
- Karolinska Institutet
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- Proietti, Carla (författare)
- James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Cairns, Qld, Australia.
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- Chang, Ellen T. (författare)
- Stanford Canc Inst, Stanford, CA USA.;Exponent Inc, Ctr Hlth Sci, Menlo Pk, CA USA.
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- Smedby, Karin E. (författare)
- Karolinska Institutet
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- Yu, Kelly J. (författare)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA.
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- Lake, Annette (författare)
- Univ Glasgow, MRC, Ctr Virus Res, Glasgow, Lanark, Scotland.
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- Troy, Sally (författare)
- James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Cairns, Qld, Australia.
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- McAulay, Karen A. (författare)
- REPROCELL Europe Ltd, Glasgow, Lanark, Scotland.
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- Pfeiffer, Ruth M. (författare)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA.
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- Adami, Hans-Olov (författare)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Oslo, Inst Hlth, Clin Effectiveness Res Grp, Oslo, Norway.
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- Glimelius, Bengt (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Melbye, Mads (författare)
- Statens Serum Inst, Copenhagen, Denmark.;Univ Copenhagen, Med Clin, Copenhagen, Denmark.;Stanford Univ, Sch Med, Stanford, CA 94305 USA.
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- Hildesheim, Allan (författare)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA.
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- Doolan, Denise L. (författare)
- James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Mol Therapeut, Cairns, Qld, Australia.
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- Coghill, Anna E. (författare)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA.;H Lee Moffitt Canc Ctr & Res Inst, Div Populat Sci, Canc Epidemiol Program, Tampa, FL USA.
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NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA Univ Glasgow, MRC, Ctr Virus Res, Glasgow, Lanark, Scotland. (creator_code:org_t)
- 2019-11-14
- 2020
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 147:3, s. 608-618
- Relaterad länk:
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http://eprints.gla.a...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The humoral immune response to Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (cHL) stratified by EBV tumor status is unclear. We examined IgG and IgA antibody responses against 202 protein sequences representing 86 EBV proteins using a microarray and sera from 139 EBV-positive cHL cases, 70 EBV-negative cHL cases and 141 population-based controls frequency matched to EBV-positive cHL cases on sex and age by area (UK, Denmark and Sweden). We leveraged existing data on the proportion of circulating B-cells infected by EBV and levels of serum CCL17, a chemokine secreted by cHL tumor cells, from a subset of the cHL cases in the UK. Total IgG but not IgA response level was significantly different between EBV-positive cHL cases and controls. The distinct serological response included significant elevations in 16 IgG antibodies and 2 IgA antibodies, with odds ratios(highest vs. lowest tertile > 3) observed for the following EBV proteins: LMP1 (oncogene), BcLF1 (VCAp160, two variants) and BBLF1 (two variants). Our cHL IgG signature correlated with the proportion of circulating EBV-infected B-cells, but not serum CCL17 levels. We observed no differences in the anti-EBV antibody profile between EBV-negative cHL cases and controls. BdRF1(VCAp40)-IgG and BZLF1(Zta)-IgG were identified as the serological markers best able to distinguish EBV-positive from EBV-negative cHL tumors. Our results support the hypothesis that differences in the EBV antibody profile are specific to patients with EBV-positive cHL and are not universally observed as part of a systematically dysregulated immune response present in all cHL cases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- EBV and cancer
- Hodgkin lymphoma
- EBV antibody patterns
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Liu, Zhiwei
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Jarrett, Ruth F.
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Hjalgrim, Henrik
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Proietti, Carla
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Chang, Ellen T.
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Smedby, Karin E.
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visa fler...
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Yu, Kelly J.
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Lake, Annette
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Troy, Sally
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McAulay, Karen A ...
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Pfeiffer, Ruth M ...
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Adami, Hans-Olov
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Glimelius, Bengt
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Melbye, Mads
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Hildesheim, Alla ...
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Doolan, Denise L ...
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Coghill, Anna E.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- Av lärosätet
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Uppsala universitet
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Karolinska Institutet