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Survival of esophag...
Survival of esophageal and gastric cancer patients with adjuvant and palliative chemotherapy-a retrospective analysis of a register-based patient cohort
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- Ekheden, Isabella (författare)
- Karolinska Institutet
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- Ebrahim, Fereshte (författare)
- Stockholm Cty Council, Reg Canc Ctr Stockholm Gotland, Vastgotagatan 2, Stockholm 10239, Sweden.
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- olafsdottir, Halla (författare)
- Karolinska Univ Hosp, Canc Theme, Stockholm 17164, Sweden.
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- Raaschou, Pauline (författare)
- Karolinska Institutet
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- Wettermark, Björn (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för farmaci,Karolinska Inst, Clin Epidemiol Sect, Dept Med Solna, Stockholm 17176, Sweden.;Karolinska Univ Hosp, Div Clin Pharmacol, Dept Lab Med LABMED, H5,C1 68, Stockholm 14186, Sweden.
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- Henriksson, Roger (författare)
- Umeå universitet,Onkologi,Regional Cancer Centre Stockholm Gotland, Stockholm County Council, Sweden,Stockholm Cty Council, Reg Canc Ctr Stockholm Gotland, Vastgotagatan 2, Stockholm 10239, Sweden.;Umeå Univ, Dept Radiat Sci, Umeå 90187, Sweden.
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- Ye, Weimin (författare)
- Karolinska Institutet
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Karolinska Institutet Stockholm Cty Council, Reg Canc Ctr Stockholm Gotland, Vastgotagatan 2, Stockholm 10239, Sweden (creator_code:org_t)
- 2020-05-05
- 2020
- Engelska.
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Ingår i: European Journal of Clinical Pharmacology. - : Springer Nature. - 0031-6970 .- 1432-1041. ; 76:7, s. 1029-1041
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Abstract
Ämnesord
Stäng
- PurposeThe survival of esophageal and gastric cancer patients treated with chemotherapy is rarely assessed outside of clinical trials. Therefore, we compared the effectiveness of various curative or palliative chemotherapy regimens on the survival of esophageal and gastric cancer patients in a “real world” clinical setting.MethodsWe identified a cohort of 966 incident esophageal and gastric cancer patients in Stockholm/Gotland County (a low-risk Western population) during 2008–2013. Patients who received chemotherapy with curative intention (n = 279) and palliative intention (n = 182) were analyzed separately. Using Cox proportional hazards regression models, we estimated hazard ratios (HRs) with 95% confidence intervals (CIs) and adjusted for the potential confounding factors: age, sex, TNM stage, radiotherapy, comorbidity, marital status, education, income, and country of birth.ResultsIn esophageal cancer patients with curative treatment intention, we observed a higher hazard for death among patients who received carboplatin-fluorouracil compared to patients who received cisplatin-fluorouracil, corresponding to a HR of 2.18 (95% CI 1.09–4.37). Conversely, in patients with cancer in the gastroesophageal junction who had a curative treatment intention at diagnosis, we observed a reduced hazard for death among those who received fluorouracil-oxaliplatin, compared to patients who received cisplatin-fluorouracil (HR 0.28; 95% CI 0.08–0.96).ConclusionAmong patients with esophageal cancer who received treatment with curative intention, cisplatin-fluorouracil was associated with better survival compared to carboplatin-fluorouracil, while patients with gastroesophageal junction cancer who were treated with cisplatin-fluorouracil had worse survival compared to fluorouracil-oxaliplatin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Esophageal cancer
- Gastric cancer
- Chemotherapy
- Adjuvant
- Palliative
- Survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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