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Radical radiotherap...
Radical radiotherapy for prostate cancer : patterns of care in Sweden 1998-2016
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- Beckmann, Kerri (författare)
- Kings Coll London, Sch Canc & Pharmaceut Studies, TOUR, London, England.;Univ South Australia, Canc Res Inst, Adelaide, SA, Australia.,King's College London,University of South Australia
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- Garmo, Hans (författare)
- Uppsala Univ Hosp, Reg Canc Ctr Uppsala, Uppsala, Sweden.,Uppsala University Hospital
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- Nilsson, Per (författare)
- Lund University,Lunds universitet,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Oncol & Radiat Phys, Lund, Sweden.;Lund Univ, Lund, Sweden.
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- Franck Lissbrant, Ingela (författare)
- Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.,Sahlgrenska Academy
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- Widmark, Anders (författare)
- Umeå University,Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
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- Stattin, Pär (författare)
- Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi,Uppsala University Hospital
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Kings Coll London, Sch Canc & Pharmaceut Studies, TOUR, London, England;Univ South Australia, Canc Res Inst, Adelaide, SA, Australia. King's College London (creator_code:org_t)
- TAYLOR & FRANCIS LTD, 2020
- 2020
- Engelska.
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Ingår i: Acta Oncologica. - : TAYLOR & FRANCIS LTD. - 0284-186X .- 1651-226X. ; 59:5, s. 549-557
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Introduction: Radiotherapy is an established treatment option for prostate cancer (PCa), both as primary treatment and secondary treatment after radical prostatectomy (RP). Since 1998, detailed data on radiotherapy delivered to Swedish men with PCa (e.g. treatment modalities, absorbed doses, fractionation) have been collated within PCa data Base Sweden (PCBaSe). This study reports patterns of radical radiotherapy for PCa in Sweden over the past two decades. Materials and methods: All men with non-metastatic PCa (1998-2016) who received external beam radiotherapy (EBRT) or high or low dose-rate brachytherapy (HDR-BT/LDR-BT) were identified in PCBaSe. Analyses included: trends in radiation techniques, fractionation patterns and total doses over time; PCa-specific survival comparing treatment in 2007-2017 with 1998-2006; and regional variation in type of primary radiotherapy. Results: About 20,876 men underwent primary radiotherapy. The main treatment modalities include conventionally fractionated (2.0 Gy/fraction) EBRT (51%), EBRT with HDR-BT boost (27%) and hypofractionated (>2.4 Gy/fraction) EBRT (11%). EBRT with photon or proton boost and HDR-BT and LDR-BT monotherapies were each used minimally. Use of dose-escalated EBRT (>74 Gy) and moderate hypofractionation increased over time, while use of HDR-BT declined. Considerable regional variation in treatment modalities was apparent. Risk of PCa death following primary radiotherapy had declined for intermediate-risk (HR: 0.60; 95%CI 0.47-0.87) and high-risk PCa (HR: 0.72; 95%CI 0.61-0.86). Discussion: Increased use of dose escalation and hypofractionated EBRT has occurred in Sweden over the past two decades, reflecting current evidence and practice guidelines. Disease-specific outcomes have also improved. Data collected in PCBaSe provide an excellent resource for further research into RT use in PCa management.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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