Sökning: id:"swepub:oai:DiVA.org:uu-425248" >
Prevention of Rat I...
Prevention of Rat Intestinal Injury with a Drug Combination of Melatonin and Misoprostol
-
- Dahlgren, David (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
- Cano-Cebrian, Maria-Jose (författare)
- Univ Valencia, Dept Pharm Pharmaceut Technol & Parasitol, Valencia 46010, Spain.
-
- Hellström, Per M., 1954- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
-
visa fler...
-
- Wanders, Alkwin (författare)
- Aalborg Univ Hosp, Dept Pathol, DK-9100 Aalborg, Denmark.
-
- Sjöblom, Markus, 1973- (författare)
- Uppsala universitet,Sjöblom/Nylander: Gastrointestinal fysiologi
-
- Lennernäs, Hans (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
-
visa färre...
-
(creator_code:org_t)
- 2020-09-15
- 2020
- Engelska.
-
Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 21:18
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.mdpi.com...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- A healthy intestinal barrier prevents uptake of allergens and toxins, whereas intestinal permeability increases following chemotherapy and in many gastrointestinal and systemic diseases and disorders. Currently, there are no approved drugs that target and repair the intestinal epithelial barrier while there is a medical need for such treatment in gastrointestinal and related conditions. The objective of this single-pass intestinal perfusion study in rats was to investigate the preventive cytoprotective effect of three mucosal protective drugs-melatonin, misoprostol, and teduglutide-with different mechanisms of action on an acute jejunal injury induced by exposing the intestine for 15 min to the anionic surfactant, sodium dodecyl sulfate (SDS). The effect was evaluated by monitoring intestinal clearance of Cr-51-labeled ethylenediaminetetraacetate and intestinal histology before, during, and after luminal exposure to SDS. Our results showed that separate pharmacological pretreatments with luminal misoprostol and melatonin reduced acute SDS-induced intestinal injury by 47% and 58%, respectively, while their use in combination abolished this injury. This data supports further development of drug combinations for oral treatments of conditions and disorders related to a dysregulated or compromised mucosal epithelial barrier.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- intestinal barrier dysfunction
- single-pass intestinal perfusion
- intestinal permeability
- gastrointestinal physiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas