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Sökning: id:"swepub:oai:DiVA.org:uu-428999" > Radiation-induced a...

Radiation-induced accelerated aging of the brain vasculature in young adult survivors of childhood brain tumors

Remes, Tiina Maria (författare)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
Suo-Palosaari, Maria Helena (författare)
Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, Oulu, Finland; Univ Oulu, Med Res Ctr Oulu, Oulu, Finland
Koskenkorva, Päivi K. T. (författare)
Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
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Sutela, Anna K. (författare)
Kuopio Univ Hosp, Dept Clin Radiol, Kuopio, Finland
Toiviainen-Salo, Sanna-Maria (författare)
Univ Helsinki, HUS Med Imaging Ctr, Dept Pediat Radiol, Radiol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
Arikoski, Pekka M. (författare)
Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland
Arola, Mikko O. (författare)
Tampere Univ Hosp, Dept Pediat, Tampere, Finland; Univ Tampere, Tampere, Finland
Heikkilä, Vesa-Pekka (författare)
Oulu Univ Hosp, Dept Oncol & Radiotherapy, Oulu, Finland
Kapanen, Mika (författare)
Tampere Univ Hosp, Dept Oncol, Tampere, Finland; Tampere Univ Hosp, Dept Med Phys, Tampere, Finland
Lähteenmäki, Päivi Maria (författare)
Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland; Turku Univ, Turku, Finland
Lönnqvist, Tuula R. I. (författare)
Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland
Niiniviita, Hannele (författare)
Turku Univ Hosp, Dept Med Phys, Div Med Imaging, Turku, Finland
Pokka, Tytti M.-L. (författare)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
Porra, Liisa (författare)
Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Oncol, Helsinki, Finland
Riikonen, V. Pekka (författare)
Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland
Seppälä, Jan (författare)
Kuopio Univ Hosp, Ctr Oncol, Kuopio, Finland
Sirkiä, Kirsti H. (författare)
Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland
Vanhanen, Antti (författare)
Tampere Univ Hosp, Dept Oncol, Tampere, Finland; Tampere Univ Hosp, Dept Med Phys, Tampere, Finland
Rantala, Heikki M. J. (författare)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
Harila-Saari, Arja H. (författare)
Uppsala universitet,Barnneurologi/Barnonkologi
Ojaniemi, Marja K. (författare)
Oulu Univ Hosp, Dept Pediat & Adolescence, PEDEGO Res Unit, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
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 (creator_code:org_t)
2020-02-07
2020
Engelska.
Ingår i: Neuro-Oncology Practice. - : Oxford University Press (OUP). - 2054-2577 .- 2054-2585. ; 7:4, s. 415-427
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BackgroundCranial radiotherapy may damage the cerebral vasculature. The aim of this study was to understand the prevalence and risk factors of cerebrovascular disease (CVD) and white matter hyperintensities (WMHs) in childhood brain tumors (CBT) survivors treated with radiotherapy.MethodsSeventy CBT survivors who received radiotherapy were enrolled in a cross-sectional study at a median 20 years after radiotherapy cessation. The prevalence of and risk factors for CVD were investigated using MRI, MRA, and laboratory testing. Tumors, their treatment, and stroke-related data were retrieved from patients’ files.ResultsForty-four individuals (63%) had CVD at a median age of 27 years (range, 16-43 years). The prevalence rates at 20 years for CVD, small-vessel disease, and large-vessel disease were 52%, 38%, and 16%, respectively. Ischemic infarcts were diagnosed in 6 survivors, and cerebral hemorrhage in 2. Lacunar infarcts were present in 7, periventricular or deep WMHs in 34 (49%), and mineralizing microangiopathy in 21 (30%) survivors. Multiple pathologies were detected in 44% of the participants, and most lesions were located in a high-dose radiation area. Higher blood pressure was associated with CVD and a presence of WMHs. Higher cholesterol levels increased the risk of ischemic infarcts and WMHs, and lower levels of high-density lipoprotein and higher waist circumference increased the risk of lacunar infarcts.ConclusionsTreating CBTs with radiotherapy increases the risk of early CVD and WMHs in young adult survivors. These results suggest an urgent need for investigating CVD prevention in CBT patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

brain tumor
cerebrovascular disease
radiotherapy
stroke
survivor

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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