Sökning: id:"swepub:oai:DiVA.org:uu-431278" >
TGFBR3L-An Uncharac...
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.
-
- Sjostedt, Evelina (författare)
- Karolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden.;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.
-
- Kolnes, Anders J (författare)
- Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
-
- Olarescu, Nicoleta C (författare)
- Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
-
visa fler...
-
- Mitsios, Nicholas (författare)
- Karolinska Institutet
-
- Hikmet Noraddin, Feria (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.
-
- Sivertsson, Åsa (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
-
- Lindskog, Cecilia (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.
-
- Øystese, Kristin A B (författare)
- Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
-
- Jørgensen, Anders P (författare)
- Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
-
- Bollerslev, Jens (författare)
- Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway.
-
- Casar Borota, Olivera (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden.;Oslo Univ Hosp, Rikshosp, Dept Pathol, Pb 4950, N-0424 Oslo, Norway.
-
visa färre...
-
Karolinska Inst, Dept Neurosci, Solnavagen 1, S-17177 Solna, Sweden;Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjoldsvag 20, S-75237 Uppsala, Sweden. Oslo Univ Hosp, Rikshosp, Dept Endocrinol, Sect Specialized Endocrinol, Pb 4950, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Box 1072, N-0316 Oslo, Norway. (creator_code:org_t)
- 2020-12-31
- 2020
- Engelska.
-
Ingår i: Cancers. - BASEL SWITZERLAND : MDPI AG. - 2072-6694. ; 13:1
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://www.mdpi.com...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for TGFBR3L staining and combined with SF1 and FSH for a 3-plex fluorescent protocol, providing more details about the cell lineage specificity of TGFBR3L expression. A cohort of 230 pituitary neuroendocrine tumours were analysed. In a subgroup of previously characterised gonadotroph tumours, correlation with expression of FSH/LH, E-cadherin, oestrogen (ER) and somatostatin receptors (SSTR) was explored. TGFBR3L showed membranous immunolabeling and was found to be gonadotroph cell lineage-specific, verified by co-expression with SF1 and FSH/LH staining in both tumour and non-neoplastic anterior pituitary tissues. TGFBR3L immunoreactivity was observed in gonadotroph tumours only and demonstrated intra-tumour heterogeneity with a perivascular location. TGFBR3L immunostaining correlated positively to both FSH (R = 0.290) and LH (R = 0.390) immunostaining, and SSTR3 (R = 0.315). TGFBR3L correlated inversely to membranous E-cadherin staining (R = -0.351) and oestrogen receptor β mRNA (R = -0.274). In conclusion, TGFBR3L is a novel pituitary gland specific protein, located in the membrane of gonadotroph cells in non-neoplastic anterior pituitary gland and in a subset of gonadotroph pituitary tumours.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- gonadotroph cells
- hormone secretion
- immunohistochemistry
- membrane protein
- pituitary gland
- pituitary neuroendocrine tumours
- Patologi
- Pathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Sjostedt, Evelin ...
-
Kolnes, Anders J
-
Olarescu, Nicole ...
-
Mitsios, Nichola ...
-
Hikmet Noraddin, ...
-
Sivertsson, Åsa
-
visa fler...
-
Lindskog, Cecili ...
-
Øystese, Kristin ...
-
Jørgensen, Ander ...
-
Bollerslev, Jens
-
Casar Borota, Ol ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Klinisk laborato ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Cancers
- Av lärosätet
-
Uppsala universitet
-
Kungliga Tekniska Högskolan
-
Karolinska Institutet