Sökning: id:"swepub:oai:DiVA.org:uu-431509" >
Validation of a dia...
Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD
-
- Karlsson, Niklas (författare)
- BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden
-
- Atkinson, Mark J. (författare)
- Evidera, Bethesda, MD, USA
-
- Müllerová, Hana (författare)
- BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK
-
visa fler...
-
- Alacqua, Marianna (författare)
- BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK
-
Keen, Christina (författare)
-
Hughes, Rod (författare)
-
- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
-
Make, Barry (författare)
-
Price, David (författare)
-
Reddel, Helen K. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2020-11-26
- 2021
- Engelska.
-
Ingår i: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 7:1
- Relaterad länk:
-
https://openres.ersj...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background he Respiratory Symptoms Questionnaire (RSQ) is a novel, 4-item patient-reported diagnosis-agnostic tool designed to assess the frequency of respiratory symptoms and their impact on activity, without specifying a particular diagnosis. Our objective was to examine its validity in patients with asthma and/or chronic obstructive pulmonary disease (COPD).Methods Baseline data were randomly sampled from patients who completed the RSQ in the NOVELTY study (NCT02760329). The total sample (N=1530) comprised three randomly selected samples (N=510 each) from each physician-assigned diagnostic group (asthma, asthma+COPD, COPD). The internal consistency and structural validity of the RSQ were evaluated using exploratory and confirmatory factor analyses; psychometric performance was observed using Classical Test Theory and Item Response Theory analyses.Results For the total sample, the mean RSQ score was 5.6 (sd 4.3; range: 0–16). Irrespective of diagnosis, the internal consistency of items was uniformly adequate (Cronbach's alphas range: 0.76–0.80). All items had high factor loadings, and structural characteristics of the measure were invariant across groups. Using the total sample, RSQ items informatively covered the theta score range of –2.0 to 2.8, with discrimination coefficients for individual items being high-to-very high (1.7–2.6). Strong convergent correlations were observed between the RSQ and St George's Respiratory Questionnaire (SGRQ; 0.77, p<0.001).Conclusions he RSQ is a valid, brief, patient-reported tool for assessing respiratory symptoms in patients across the whole spectrum of asthma and/or COPD, rather than using different questionnaires for each diagnosis. It can be used for monitoring respiratory symptoms in clinical practice, clinical trials and real-world studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Lung Medicine
- Lungmedicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Karlsson, Niklas
-
Atkinson, Mark J ...
-
Müllerová, Hana
-
Alacqua, Mariann ...
-
Keen, Christina
-
Hughes, Rod
-
visa fler...
-
Janson, Christer
-
Make, Barry
-
Price, David
-
Reddel, Helen K.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Lungmedicin och ...
- Artiklar i publikationen
-
ERJ Open Researc ...
- Av lärosätet
-
Uppsala universitet