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Universal probabili...
Universal probabilistic programming offers a powerful approach to statistical phylogenetics
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- Ronquist, Fredrik (författare)
- Swedish Museum of Natural History
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- Kudlicka, Jan (författare)
- Uppsala universitet,Avdelningen för datalogi,Datalogi
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- Senderov, Viktor (författare)
- Swedish Museum of Natural History
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- Borgström, Johannes (författare)
- Uppsala universitet,Avdelningen för datalogi,Datalogi
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- Lartillot, Nicolas (författare)
- Université Claude Bernard Lyon 1
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- Lundén, Daniel (författare)
- KTH Royal Institute of Technology
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- Murray, Lawrence M. (författare)
- Uber AI
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- Schön, Thomas B., Professor, 1977- (författare)
- Uppsala universitet,Avdelningen för systemteknik,Artificiell intelligens
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- Broman, David (författare)
- KTH Royal Institute of Technology
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(creator_code:org_t)
- Springer Nature, 2021
- 2021
- Engelska.
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Ingår i: Communications Biology. - : Springer Nature. - 2399-3642. ; 4
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://uu.diva-porta...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Statistical phylogenetic analysis currently relies on complex, dedicated software packages, making it difficult for evolutionary biologists to explore new models and inference strategies. Recent years have seen more generic solutions based on probabilistic graphical models, but this formalism can only partly express phylogenetic problems. Here, we show that universal probabilistic programming languages (PPLs) solve the expressivity problem, while still supporting automated generation of efficient inference algorithms. To prove the latter point, we develop automated generation of sequential Monte Carlo (SMC) algorithms for PPL descriptions of arbitrary biological diversification (birth-death) models. SMC is a new inference strategy for these problems, supporting both parameter inference and efficient estimation of Bayes factors that are used in model testing. We take advantage of this in automatically generating SMC algorithms for several recent diversification models that have been difficult or impossible to tackle previously. Finally, applying these algorithms to 40 bird phylogenies, we show that models with slowing diversification, constant turnover and many small shifts generally explain the data best. Our work opens up several related problem domains to PPL approaches, and shows that few hurdles remain before these techniques can be effectively applied to the full range of phylogenetic models.
Ämnesord
- NATURVETENSKAP -- Matematik -- Sannolikhetsteori och statistik (hsv//swe)
- NATURAL SCIENCES -- Mathematics -- Probability Theory and Statistics (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Datavetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Computer Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
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