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Dental Calculus as ...
Dental Calculus as a Tool to Study the Evolution of the Mammalian Oral Microbiome
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- Brealey, Jaelle C. (författare)
- Uppsala universitet,Zooekologi
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- Leitao, Henrique G. (författare)
- Uppsala universitet,Zooekologi
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- van der Valk, Tom (författare)
- Uppsala universitet,Zooekologi
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- Xu, Wenbo (författare)
- Uppsala universitet,Zooekologi
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- Bougiouri, Katia (författare)
- Uppsala universitet,Zooekologi
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- Dalén, Love (författare)
- Naturhistoriska riksmuseet,Enheten för bioinformatik och genetik,Swedish Museum Nat Hist, Dept Bioinformat & Genet, Stockholm, Sweden.;Ctr Palaeogenet, Stockholm, Sweden.
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- Guschanski, Katerina, Dr. 1978- (författare)
- Uppsala universitet,Zooekologi
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(creator_code:org_t)
- 2020-05-28
- 2020
- Engelska.
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Ingår i: Molecular biology and evolution. - : OXFORD UNIV PRESS. - 0737-4038 .- 1537-1719. ; 37:10, s. 3003-3022
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Dental calculus, the calcified form of the mammalian oral microbial plaque biofilm, is a rich source of oral microbiome, host, and dietary biomolecules and is well preserved in museum and archaeological specimens. Despite its wide presence in mammals, to date, dental calculus has primarily been used to study primate microbiome evolution. We establish dental calculus as a valuable tool for the study of nonhuman host microbiome evolution, by using shotgun metagenomics to characterize the taxonomic and functional composition of the oral microbiome in species as diverse as gorillas, bears, and reindeer. We detect oral pathogens in individuals with evidence of oral disease, assemble near-complete bacterial genomes from historical specimens, characterize antibiotic resistance genes, reconstruct components of the host diet, and recover host genetic profiles. Our work demonstrates that metagenomic analyses of dental calculus can be performed on a diverse range of mammalian species, which will allow the study of oral microbiome and pathogen evolution from a comparative perspective. As dental calculus is readily preserved through time, it can also facilitate the quantification of the impact of anthropogenic changes on wildlife and the environment.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- metagenomics
- ancient DNA
- antimicrobial resistance
- metagenome-assembled genomes
- oral pathogens
- Diversity of life
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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