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Prenatal methylmerc...
Prenatal methylmercury exposure and DNA methylation in seven-year-old children in the Seychelles Child Development Study
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- Cediel Ulloa, Andrea (författare)
- Uppsala University,Karolinska Institute,Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, Box 210, S-17177 Stockholm, Sweden
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- Gliga, Anda (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Box 210, S-17177 Stockholm, Sweden
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- Love, Tanzy M. (författare)
- Univ Rochester, Sch Med & Dent, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA,University of Rochester
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- Pineda, Daniela (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,Lund Univ, Div Occupat & Environm Med, Dept Lab Med, Scheelevagen 8, S-22185 Lund, Sweden
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- Mruzek, Daniel W. (författare)
- Univ Rochester, Sch Med & Dent, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA,University of Rochester
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- Watson, Gene E. (författare)
- Univ Rochester, Sch Med & Dent, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA,University of Rochester
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- Davidson, Philip W. (författare)
- Univ Rochester, Sch Med & Dent, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA,University of Rochester
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- Shamlaye, Conrad F. (författare)
- Minist Hlth, Child Dev Ctr, Mahe, Seychelles,Ministry of Health, Seychelles
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- Strain, J. J. (författare)
- Ulster Univ, Nutr Innovat Ctr Food & Hlth NICHE, Coleraine BT52 1SA, Londonderry, North Ireland,University of Ulster
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- Myers, Gary J. (författare)
- Univ Rochester, Sch Med & Dent, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA,University of Rochester
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- van Wijngaarden, Edwin (författare)
- Univ Rochester, Sch Med & Dent, Med Ctr, 601 Elmwood Ave, Rochester, NY 14642 USA,University of Rochester
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- Ruegg, Joelle (författare)
- Karolinska Institutet,Uppsala University,Uppsala universitet,Miljötoxikologi
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- Broberg, Karin (författare)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Institute of Occupational Medicine and Environmental Health,Karolinska Inst, Inst Environm Med, Box 210, S-17177 Stockholm, Sweden; Lund Univ, Div Occupat & Environm Med, Dept Lab Med, Scheelevagen 8, S-22185 Lund, Sweden
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 147
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundMethylmercury (MeHg) is present in fish and is a neurotoxicant at sufficiently high levels. One potential mechanism of MeHg toxicity early in life is epigenetic dysregulation that may affect long-term neurodevelopment. Altered DNA methylation of nervous system-related genes has been associated with adult mental health outcomes.ObjectiveTo assess associations between prenatal MeHg exposure and DNA methylation (at the cytosine of CG dinucleotides, CpGs) in three nervous system-related genes, encoding brain-derived neurotropic factor (BDNF), glutamate receptor subunit NR2B (GRIN2B), and the glucocorticoid receptor (NR3C1), in children who were exposed to MeHg in utero.MethodsWe tested 406 seven-year-old Seychellois children participating in the Seychelles Child Development Study (Nutrition Cohort 2), who were prenatally exposed to MeHg from maternal fish consumption. Total mercury in maternal hair (prenatal MeHg exposure measure) collected during pregnancy was measured using atomic absorption spectroscopy. Methylation in DNA from the children’s saliva was measured by pyrosequencing. To assess associations between prenatal MeHg exposure and CpG methylation at seven years of age, we used multivariable linear regression models adjusted for covariates.ResultsWe identified associations with prenatal MeHg exposure for DNA methylation of one GRIN2B CpG and two NR3C1 CpGs out of 12 total CpG sites. Higher prenatal MeHg was associated with higher methylation for each CpG site. For example, NR3C1 CpG3 had an expected increase of 0.03-fold for each additional 1 ppm of prenatal MeHg (B = 0.030, 95% CI 0.001, 0.059; p = 0.047). Several CpG sites associated with MeHg are located in transcription factor binding sites and the observed methylation changes are predicted to lead to lower gene expression.ConclusionsIn a population of people who consume large amounts of fish, we showed that higher prenatal MeHg exposure was associated with differential DNA methylation at seven years of age at specific CpG sites that may influence neurodevelopment and mental health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Methylmercury
- MeHg
- Epigenetic
- DNA methylation
- Neurodevelopment
- Fish consumption
- Early life
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Cediel Ulloa, An ...
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Gliga, Anda
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Love, Tanzy M.
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Pineda, Daniela
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Mruzek, Daniel W ...
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Watson, Gene E.
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visa fler...
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Davidson, Philip ...
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Shamlaye, Conrad ...
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Strain, J. J.
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Myers, Gary J.
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van Wijngaarden, ...
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Ruegg, Joelle
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Broberg, Karin
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Environment Inte ...
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet