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Polyphenol-rich extract of Zhenjiang aromatic vinegar ameliorates high glucose-induced insulin resistance by regulating JNK-IRS-1 and PI3K/Akt signaling pathways
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- Xia, Ting (author)
- Tianjin Univ Sci & Technol, Coll Biotechnol, Key Lab Ind Fermentat Microbiol, State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China.
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- Duan, Wenhui (author)
- Tianjin Univ Sci & Technol, Coll Biotechnol, Key Lab Ind Fermentat Microbiol, State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China.
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- Zhang, Zhujun (author)
- Tianjin Univ Sci & Technol, Coll Biotechnol, Key Lab Ind Fermentat Microbiol, State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China.
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- Tianjin Univ Sci & Technol, Coll Biotechnol, Key Lab Ind Fermentat Microbiol, State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China Natl Univ San Marcos, Ctr Latinoamericano Ensenanza & Invest Bacteriol, Fac Pharm & Biochem, Lima, Peru. (creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
- In: Food Chemistry. - : Elsevier. - 0308-8146 .- 1873-7072. ; 335
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Zhenjiang aromatic vinegar is a famous traditional fermented cooking ingredient in China, with multiple nutritional and medicinal applications. Zhenjiang aromatic vinegar extract (100-400 mu g/mL) is rich in polyphenols increased the glucose uptake and glucose consumption in high glucose-induced insulin resistant HepG2 (IR-HepG2) cells. Zhenjiang aromatic vinegar extract enhanced glycogen synthesis and attenuated gluconeogenesis by regulating key enzymes in IR-HepG2 cells. In addition, Zhenjiang aromatic vinegar extract ameliorated high glucose-induced IR by inhibiting phosphorylated insulin receptor substrate-1 (IRS-1) expression and activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells. Moreover, Zhenjiang aromatic vinegar extract reduced reactive oxygen species generation and phosphorylated c-Jun NH2 terminal kinase (JNK) expression in IR-HepG2 cells. The attenuation of the high glucose is owned to the PI3K/Akt pathway activation, glycogen synthesis induction and gluconeogenesis suppression in IR-HepG2 cells.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Insulin resistance
- JNK-IRS-1
- PI3K/Akt
- Vinegar extract
- Polyphenols
- HepG2 cells
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Duan, Wenhui
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- Uppsala University
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