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Three-dimensional t...
Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging
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- Li, Hao, 1984- (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Helpard, Luke (författare)
- Western Univ, Sch Biomed Engn, 1152 Richmond St, London, ON N6A 3K7, Canada.
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- Ekeroot, Jonas (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Rohani, Seyed Alireza (författare)
- Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.
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- Zhu, Ning (författare)
- Univ Saskatchewan, Canadian Light Source Inc, Biomed Imaging & Therapy Facil, Saskatoon, SK, Canada.
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- Rask-Andersen, Helge (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Ladak, Hanif M. (författare)
- Western Univ, Sch Biomed Engn, 1152 Richmond St, London, ON N6A 3K7, Canada.;Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.;Western Univ, Dept Med Biophys, London, ON, Canada.;Western Univ, Dept Elect & Comp Engn, London, ON, Canada.
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- Agrawal, Sumit (författare)
- Western Univ, Sch Biomed Engn, 1152 Richmond St, London, ON N6A 3K7, Canada.;Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada.;Western Univ, Dept Med Biophys, London, ON, Canada.;Western Univ, Dept Elect & Comp Engn, London, ON, Canada.
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(creator_code:org_t)
- 2021-02-24
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The human cochlea transforms sound waves into electrical signals in the acoustic nerve fibers with high acuity. This transformation occurs via vibrating anisotropic membranes (basilar and tectorial membranes) and frequency-specific hair cell receptors. Frequency-positions can be mapped within the cochlea to create a tonotopic chart which fits an almost-exponential function with lowest frequencies positioned apically and highest frequencies positioned at the cochlear base (Bekesy 1960, Greenwood 1961). To date, models of frequency positions have been based on a two-dimensional analysis with inaccurate representations of the cochlear hook region. In the present study, the first three-dimensional frequency analysis of the cochlea using dendritic mapping to obtain accurate tonotopic maps of the human basilar membrane/organ of Corti and the spiral ganglion was performed. A novel imaging technique, synchrotron radiation phase-contrast imaging, was used and a spiral ganglion frequency function was estimated by nonlinear least squares fitting a Greenwood-like function (F=A (10(ax) - K)) to the data. The three-dimensional tonotopic data presented herein has large implications for validating electrode position and creating customized frequency maps for cochlear implant recipients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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