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Increased levels of...
Increased levels of the cardiovascular disease risk biomarkers GDF15 and myostatin in patients with chronic lymphocytic leukemia
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- Larsson, Karin (author)
- Uppsala universitet,Hematologi
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Thulin, Måns (author)
- School of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Edinburgh, UK
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- Karlsson, Torbjörn (author)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- 2021-06-14
- 2021
- English.
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In: Growth Factors. - : Informa UK Limited. - 0897-7194 .- 1029-2292. ; 38:3-4, s. 189-196
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Abstract
Subject headings
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- Individuals suffering from cancer, including hematological malignancies, are at increased risk of cardiovascular disease (CVD). Elevated levels of several biomarkers in blood are associated with an increased risk of CVD. The aim of this study was to investigate whether a subset of such CVD risk biomarkers was elevated in patients with untreated chronic lymphocytic leukemia (CLL). Blood plasma and serum from 139 CLL patients and 71 healthy age-matched controls were analyzed for 11 proposed CVD risk biomarkers. The CLL cohort displayed a more heterogeneous pattern of biomarker expression compared to controls. The majority, eight out of 11, analyzed CVD risk biomarkers differed significantly in concentrations between CLL patients and controls. Increased levels of the biomarkers GDF15 and myostatin have not previously been reported in CLL. Further prospective studies are warranted to investigate whether these biomarkers predict future cardiovascular events in patients with CLL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Chronic lymphocytic leukemia
- cardiovascular disease biomarkers
- cytokines
- inflammation biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
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