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A unique view of SA...
A unique view of SARS-CoV-2 through the lens of ORF8 protein
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- Hassan, Sk Sarif (författare)
- Pingla Thana Mahavidyalaya, Dept Math, Maligram 721140, India
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- Aljabali, Alaa A. A. (författare)
- Yarmouk Univ, Dept Pharmaceut & Pharmaceut Technol, Fac Pharm, Irbid 566, Jordan
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- Panda, Pritam Kumar, PhD Student, 1991- (författare)
- Uppsala universitet,Materialteori
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- Ghosh, Shinjini (författare)
- Univ Calcutta, Dept Biophys, Mol Biol & Bioinformat, Kolkata 700009, W Bengal, India
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- Attrish, Diksha (författare)
- Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Kolkata 700009, W Bengal, India
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- Choudhury, Pabitra Pal (författare)
- Univ Delhi North Campus, Dr BR Ambedkar Ctr Biomed Res ACBR, Delhi 110007, India
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- Seyran, Murat (författare)
- Indian Stat Inst, Appl Stat Unit, Kolkata 700108, India
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- Pizzol, Damiano (författare)
- Univ Vienna, Doctoral Studies Nat & Tech Sci SPL 44, Vienna, Austria
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- Adadi, Parise (författare)
- Italian Agcy Dev Cooperat Khartoum, Sudan St 33, Amarat, Sudan
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- Abd El-Aziz, Tarek Mohamed (författare)
- Univ Otago, Dept Food Sci, Dunedin 9054, New Zealand; Minia Univ, Dept Zool, Fac Sci, El Minia 61519, Egypt
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- Soares, Antonio (författare)
- Minia Univ, Dept Zool, Fac Sci, El Minia 61519, Egypt
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- Kandimalla, Ramesh (författare)
- Univ Texas Hlth Sci Ctr, Dept Cellular & Integrat Physiol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA
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- Lundstrom, Kenneth (författare)
- CSIR Indian Inst Chem Technol, Uppal Rd, Hyderabad 500007, Telangana, India
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- Lal, Amos (författare)
- PanTherapeutics, Rte Lavaux 49, CH-1095 Lutry, Switzerland
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- Azad, Gajendra Kumar (författare)
- Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA
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- Uversky, Vladimir N. (författare)
- Univ Patna, Dept Zool, Patna 800005, Bihar, India
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- Sherchan, Samendra P. (författare)
- Univ S Florida, Dept Mol Med, Morsani Coll Med, Tampa, FL 33612 USA
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- Baetas-da-Cruz, Wagner (författare)
- Tulane Univ, Dept Environm Hlth Sci, New Orleans, LA 70112 USA
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- Uhal, Bruce D. (författare)
- Fed Univ Rio Janeiro UFRJ, Coll Med, Ctr Expt Surg, Translat Lab Mol Physiol, Rio De Janeiro, Brazil
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- Rezaei, Nima (författare)
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden
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- Chauhan, Gaurav (författare)
- Tecnol Monterrey, Sch Sci & Engn, Av Eugenio Garza Sada 2501, Monterrey 64849, NL, Mexico
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- Barh, Debmalya (författare)
- Inst Integrat Omics & Appl Biotechnol IIOAB, Ctr Genom & Appl Gene Technol, PatnaPatna, India
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- Redwan, Elrashdy M. (författare)
- King Abdulazizi Univ, Dept Biol Sci, Fac Sci, King, Saudi Arabia
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- Dayhoff II, Guy W. (författare)
- Univ S Florida, Dept Chem, Coll Art & Sci, Tampa, FL 33620 USA
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- Bazan, Nicolas G. (författare)
- Karolinska Institutet
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- Serrano-Aroca, Angel (författare)
- Catholic Univ Valencia San Vicente Martir, Biomat & Bioengn Lab, Translat Res Ctr San Alberto Magno, C Guillem Castro 94, Valencia 46001, Spain
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- El-Demerdash, Amr (författare)
- Inst Chim Subst Nat, Nat Prod & Med Chem Dept, Gif Sur Yvette, France
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- Mishra, Yogendra K. (författare)
- Univ Southern Denmark, Mads Clausen Inst, NanoSYD, Alsion 2, DK-6400 Sonderborg, Denmark
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- Palu, Giorgio (författare)
- Univ Padua, Dept Mol Med, Padua, Italy
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- Takayama, Kazuo (författare)
- Kyoto Univ, Ctr IPS Cell Res & Applicat, Kyoto 6068397, Japan
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- Brufsky, Adam M. (författare)
- Univ Pittsburgh, Div Hematol Oncol, Dept Med, UPMC Hillman Canc Ctr,Sch Med, Pittsburgh, PA USA
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- Tambuwala, Murtaza M. (författare)
- Univ Ulster, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Computers in Biology and Medicine. - : Elsevier BV. - 0010-4825 .- 1879-0534. ; 133
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective in reference to the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Chemical and structural properties of ORF8 proteins from different hosts, such as human, bat, and pangolin, suggest that the ORF8 of SARS-CoV-2 is much closer to ORF8 of Bat RaTG13-CoV than to that of Pangolin-CoV. Eighty-seven mutations across unique variants of ORF8 in SARS-CoV-2 can be grouped into four classes based on their predicted effects (Hussain et al., 2021) [1]. Based on the geo-locations and timescale of sample collection, a possible flow of mutations was built. Furthermore, conclusive flows of amalgamation of mutations were found upon sequence similarity analyses and consideration of the amino acid conservation phylogenies. Therefore, this study seeks to highlight the uniqueness of the rapidly evolving SARS-CoV-2 through the ORF8.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- ORF8
- Phylogenetics
- Mutational hotspots
- Physicochemical properties
- ORF8 evolution
- SARS-CoV-2
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hassan, Sk Sarif
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Aljabali, Alaa A ...
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Panda, Pritam Ku ...
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Ghosh, Shinjini
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Attrish, Diksha
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Choudhury, Pabit ...
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visa fler...
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Seyran, Murat
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Pizzol, Damiano
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Adadi, Parise
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Abd El-Aziz, Tar ...
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Soares, Antonio
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Kandimalla, Rame ...
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Lundstrom, Kenne ...
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Lal, Amos
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Azad, Gajendra K ...
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Uversky, Vladimi ...
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Sherchan, Samend ...
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Baetas-da-Cruz, ...
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Uhal, Bruce D.
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Rezaei, Nima
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Chauhan, Gaurav
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Barh, Debmalya
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Redwan, Elrashdy ...
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Dayhoff II, Guy ...
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Bazan, Nicolas G ...
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Serrano-Aroca, A ...
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El-Demerdash, Am ...
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Mishra, Yogendra ...
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Palu, Giorgio
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Takayama, Kazuo
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Brufsky, Adam M.
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Tambuwala, Murta ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Computers in Bio ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet