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Concentrations of n...
Concentrations of nine endogenous steroid hormones in 70-year-old men and women
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- Penell, Johanna Christina (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Arbets- och miljömedicin,Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,Uppsala University
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- Kushnir, Mark M. (författare)
- Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA; ARUP Inst Clin & Expt Pathol, Salt Lake City, UT USA
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi
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- Bergquist, Jonatan (författare)
- Uppsala universitet,Analytisk kemi
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi,Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA
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- Lind, P. Monica, 1957- (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Naessén, Tord (författare)
- Uppsala universitet,Reproduktionsbiologi
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(creator_code:org_t)
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- Bioscientifica, 2021
- 2021
- Engelska.
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Ingår i: Endocrine Connections. - : Bioscientifica. - 2049-3614. ; 10:5, s. 511-520
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://pub.epsilon.... (primary) (Raw object) (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- ObjectivesCirculating concentrations of endogenous steroids have systemic implications on health in elderly. However, population-based age- and ethnicity-specific data are scarce. The aim was to report sex-specific plasma concentrations of endogenous sex and adrenal steroids in elderly Swedish Caucasians, to examine the impact of BMI and to present concentrations in apparently healthy subjects.MethodsA population-based observational study of 70-year olds, including 684 community-dwelling men and women enrolled in the PIVUS study, Sweden. Median plasma concentrations were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for pregnenolone, 17-hydroxypregnenolone, 17-hydroxy-progesterone, 11-deoxycortisol, DHEA, androstenedione, testosterone, estrone and estradiol.ResultsPlasma concentrations were significantly higher in men (n = 452) than in women (n = 232) for estradiol: median 61.3 pmol/L (95% CI, 11.4, 142.7) vs 18.4 (4.0, 127.3), for estrone: 92.8 (33.3, 206) vs 71.6 (17.8, 209) pmol/L, and for testosterone 13.8 (5.7, 28.0) vs 0.7 (0.2, 2.0) nmol/L. Higher concentrations of estrone and estradiol were observed in obese than non-obese women. Compared to non-obese men, obese men had lower concentrations of testosterone and its precursors: 17-hydroxypregnenolone, 17-hydroxyprogesterone, androstenedione and DHEA. The subgroup of apparently healthy individuals had median values > 20% lower for estrone and estradiol in women but slightly higher for testosterone in both sexes.ConclusionsConcentrations of estradiol, estrone and testosterone were higher in 70-year-old men than in women. BMI associated positively to estradiol and estrone in women and negatively to testosterone in men. Apparently healthy women had lower median concentrations of estradiol and estrone and men had higher median testosterone compared to all individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- endogenous
- sex steroids
- elderly
- population-based
- liquid chromatography-tandem mass spectrometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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