Sökning: id:"swepub:oai:DiVA.org:uu-450398" >
Impact of preoperat...
Impact of preoperative breast MRI on 10-year survival outcome of patients included in the Swedish randomized multicenter POMB trial
-
- Gonzalez, Virginia (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
-
- Arver, Brita (författare)
- Department of Oncology and Pathology, Karolinska Institutet
-
- Löfgren, Lars (författare)
- Department of Surgery, S:t Goran Hospital
-
visa fler...
-
- Bergkvist, Leif (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
-
- Sandelin, Kerstin (författare)
- Department of Molecular Medicine and Surgery, Karolinska Institutet
-
- Eriksson, Staffan (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
-
visa färre...
-
(creator_code:org_t)
- 2021-10-06
- 2021
- Engelska.
-
Ingår i: BJS Open. - : Oxford University Press. - 2474-9842. ; 5:5
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- ABSTRACTBackground: The value of preoperative breast magnetic resonance imaging (MRI) as an adjunct technique regarding its effect on re-excision rates has been a subject of discussion. No survival data regarding preoperative breast MRI are available from randomized studies. Methods: Ten-year follow-up of the previous randomized multicentre study (POMB) was reported, evaluating MRI and its effect on disease-free survival (DFS) and overall survival (OS). A total of 440 patients with newly diagnosed breast cancer were randomized to either preoperative MRI (n = 220) group or conventional imaging (n = 220; control) group. Kaplan–Meier plots were used to analyze DFS and OS. Cox regression was used to estimate hazard ratios (HRs). Results: The median follow-up time for each group was 10 years. DFS rates were 85.5% and 80.0% for the MRI and control groups, respectively (P = 0.099). The risk of relapse or death was 46% higher in the control group (HR 1.46, 95% confidence interval 0.93–2.29). OS rates after 10 years were 90.9% and 88.6% for the MRI and control groups, respectively (P = 0.427). The risk of death was 27% higher in the control group (HR 1.27, 95% confidence interval 0.71–2.29). Locoregional, distant, and contralateral recurrence outcomes combined, were increased in the control group (P = 0.048). A subgroup analysis of patients with breast cancer stages I–III showed that preoperative MRI improved DFS compared with conventional imaging but this did not reach statistical significance (P = 0.057). Conclusion: After 10 years of follow-up, preoperative breast MRI as an adjunct to conventional imaging resulted in slightly, but non-significantly, improved DFS and OS.ClinicalTrials.gov Identifier: POMB NCT01859936
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Bröstcancer
- MRI
- breast cancer
- re-excision
- MRI
- survival
- Surgery
- Kirurgi
- Oncology
- Onkologi
- Radiology
- Radiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
BJS Open
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas