Sökning: id:"swepub:oai:DiVA.org:uu-451122" >
Different Inflammat...
Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
-
- Boström, Gustaf (författare)
- Uppsala universitet,Geriatrik
-
- Freyhult, Eva, 1979- (författare)
- Uppsala universitet,Cancerfarmakologi och beräkningsmedicin,Science for Life Laboratory, SciLifeLab
-
- Virhammar, Johan (författare)
- Uppsala universitet,Landtblom: Neurovetenskap
-
visa fler...
-
- Alcolea, Daniel (författare)
- Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain.;Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain.
-
- Tumani, Hayrettin (författare)
- Ulm Univ Hosp, Dept Neurol, Ulm, Germany.
-
- Otto, Markus (författare)
- Ulm Univ Hosp, Dept Neurol, Ulm, Germany.
-
- Brundin, Rose-Marie (författare)
- Uppsala universitet,Geriatrik
-
- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik
-
- Löwenmark, Malin, 1969- (författare)
- Uppsala universitet,Geriatrik
-
- Giedraitis, Vilmantas (författare)
- Uppsala universitet,Geriatrik
-
- Lleo, Alberto (författare)
- Hosp Santa Creu & Sant Pau, Neurol Dept, Memory Unit, Barcelona, Spain.;Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain.
-
- von Arnim, Christine A. F. (författare)
- Ulm Univ Hosp, Dept Neurol, Ulm, Germany.;Georg August Univ, Univ Med Ctr Gottingen, Dept Geriatr Med, Gottingen, Germany.
-
- Kultima, Kim (författare)
- Uppsala universitet,Klinisk kemi
-
- Ingelsson, Martin (författare)
- Uppsala universitet,Geriatrik
-
visa färre...
-
(creator_code:org_t)
- IOS Press, 2021
- 2021
- Engelska.
-
Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 81:2, s. 629-640
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Neuroinflammatory processes are common in neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), but current knowledge is limited as to whether cerebrospinal fluid (CSF) levels of neuroinflammatory proteins are altered in these diseases.Objective: To identify and characterize neuroinflammatory signatures in CSF from patients with AD, mild cognitive impairment (MCI), and FTD.Methods: We used proximity extension assay and ANOVA to measure and compare levels of 92 inflammatory proteins in CSF from 42 patients with AD, 29 with MCI due to AD (MCI/AD), 22 with stable MCI, 42 with FTD, and 49 control subjects, correcting for age, gender, collection unit, and multiple testing.Results: Levels of matrix metalloproteinase-10 (MMP-10) were increased in AD, MCI/AD, and FTD compared with controls (AD: fold change [FC] = 1.32, 95% confidence interval [CI] 1.14-1.53, q = 0.018; MCI/AD: FC = 1.53, 95% CI 1.20-1.94, q = 0.045; and FTD: FC = 1.42, 95% CI 1.10-1.83, q = 0.020). MMP-10 and eleven additional proteins were increased in MCI/AD, compared with MCI (q < 0.05). In FTD, 36 proteins were decreased, while none was decreased in AD or MCI/AD, compared with controls (q < 0.05).Conclusion: In this cross-sectional multi-center study, we found distinct patterns of CSF inflammatory marker levels in FTD and in both early and established AD, suggesting differing neuroinflammatory processes in the two disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- frontotemporal dementia
- mild cognitive impairment
- neuroinflammation
- proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Boström, Gustaf
-
Freyhult, Eva, 1 ...
-
Virhammar, Johan
-
Alcolea, Daniel
-
Tumani, Hayretti ...
-
Otto, Markus
-
visa fler...
-
Brundin, Rose-Ma ...
-
Kilander, Lena
-
Löwenmark, Malin ...
-
Giedraitis, Vilm ...
-
Lleo, Alberto
-
von Arnim, Chris ...
-
Kultima, Kim
-
Ingelsson, Marti ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Journal of Alzhe ...
- Av lärosätet
-
Uppsala universitet