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The proteome of the...
The proteome of the human endolymphatic sac endolymph
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- Ölander, Christine (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Edvardsson Rasmussen, Jesper (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Eriksson, Per Olof (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Laurell, Göran (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Rask-Andersen, Helge (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi
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(creator_code:org_t)
- 2021-06-04
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The endolymphatic sac (ES) is the third part of the inner ear, along with the cochlea and vestibular apparatus. A refined sampling technique was developed to analyse the proteomics of ES endolymph. With a tailored solid phase micro-extraction probe, five ES endolymph samples were collected, and six sac tissue biopsies were obtained in patients undergoing trans-labyrinthine surgery for sporadic vestibular schwannoma. The samples were analysed using nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to identify the total number of proteins. Pathway identification regarding molecular function and protein class was presented. A total of 1656 non-redundant proteins were identified, with 1211 proteins detected in the ES endolymph. A total of 110 proteins were unique to the ES endolymph. The results from the study both validate a strategy for in vivo and in situ human sampling during surgery and may also form a platform for further investigations to better understand the function of this intriguing part of the inner ear.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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