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Quantitative compar...
Quantitative comparison of data-driven gating and external hardware gating for 18F-FDG PET-MRI in patients with esophageal tumors
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- Kvernby, Sofia (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Phys, Entrance 85, SE-75185 Uppsala, Sweden.
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- Korsavidou Hult, Nafsika (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Entrance 85, SE-75185 Uppsala, Sweden.
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- Lindström, Elin (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Phys, Entrance 85, SE-75185 Uppsala, Sweden.
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- Sigfridsson, Jonathan (författare)
- Uppsala Univ Hosp, Med Imaging Ctr, Entrance 85, SE-75185 Uppsala, Sweden.
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- Linder, Gustav (författare)
- Uppsala universitet,Gastrointestinalkirurgi
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- Hedberg, Jakob, 1972- (författare)
- Uppsala universitet,Gastrointestinalkirurgi
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- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Entrance 85, SE-75185 Uppsala, Sweden.;Antaros Med AB, Mölndal, Sweden.
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- Bjerner, Tomas, 1965- (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Entrance 85, SE-75185 Uppsala, Sweden.
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Phys, Entrance 85, SE-75185 Uppsala, Sweden.
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(creator_code:org_t)
- 2021-03-23
- 2021
- Engelska.
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Ingår i: European Journal of Hybrid Imaging. - : Springer Nature. - 2510-3636. ; 5:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BackgroundRespiratory motion during PET imaging reduces image quality. Data-driven gating (DDG) based on principal component analysis (PCA) can be used to identify respiratory signals. The use of DDG, without need for external devices, would greatly increase the feasibility of using respiratory gating in a routine clinical setting. The objective of this study was to evaluate data-driven gating in relation to external hardware gating and regular static image acquisition on PET-MRI data with respect to SUVmax and lesion volumes.MethodsSixteen patients with esophageal or gastroesophageal cancer (Siewert I and II) underwent a 6-min PET scan on a Signa PET-MRI system (GE Healthcare) 1.5-2 h after injection of 4 MBq/kg F-18-FDG. External hardware gating was done using a respiratory bellow device, and DDG was performed using MotionFree (GE Healthcare). The DDG raw data files and the external hardware-gating raw files were created on a Matlab-based toolbox from the whole 6-min scan LIST-file. For comparison, two 3-min static raw files were created for each patient. Images were reconstructed using TF-OSEM with resolution recovery with 2 iterations, 28 subsets, and 3-mm post filter. SUVmax and lesion volume were measured in all visible lesions, and noise level was measured in the liver. Paired t-test, linear regression, Pearson correlation, and Bland-Altman analysis were used to investigate difference, correlation, and agreement between the methods.ResultsA total number of 30 lesions were included in the study. No significant differences between DDG and external hardware-gating SUVmax or lesion volumes were found, but the noise level was significantly reduced in the DDG images. Both DDG and external hardware gating demonstrated significantly higher SUVmax (9.4% for DDG, 10.3% for external hardware gating) and smaller lesion volume (- 5.4% for DDG, - 6.6% for external gating) in comparison with non-gated static images.ConclusionsData-driven gating with MotionFree for PET-MRI performed similar to external device gating for esophageal lesions with respect to SUVmax and lesion volume. Both gating methods significantly increased the SUVmax and reduced the lesion volume in comparison with non-gated static acquisition. DDG resulted in reduced image noise compared to external device gating and static images.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Respiratory gating
- DDG
- PET-MRI
- Esophageal tumors
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- art (ämneskategori)
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Kvernby, Sofia
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Korsavidou Hult, ...
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Lindström, Elin
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Sigfridsson, Jon ...
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Linder, Gustav
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Hedberg, Jakob, ...
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Ahlström, Håkan, ...
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Bjerner, Tomas, ...
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Lubberink, Mark
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