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How Early-Life Gut ...
How Early-Life Gut Microbiota Alteration Sets Trajectories for Health and Inflammatory Bowel Disease?
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- Guo, Feilong (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Nanjing Univ, Sch Med, Jinling Hosp, Dept Gen Surg, Nanjing, Peoples R China.
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- Cai, Demin (författare)
- Yangzhou Univ, Dept Anim Nutr, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China.;Yangzhou Univ, Epigenet & Epigenome Res Inst, Yangzhou, Jiangsu, Peoples R China.
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- Li, Yanwei (författare)
- Yangzhou Univ, Dept Anim Nutr, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China.
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- Gu, Haotian (författare)
- Yangzhou Univ, Dept Anim Nutr, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China.
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- Qu, Huan (författare)
- Yangzhou Univ, Dept Anim Nutr, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China.
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- Zong, Qiufang (författare)
- Yangzhou Univ, Dept Anim Nutr, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China.
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- Bao, Wenbin (författare)
- Yangzhou Univ, Dept Anim Nutr, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China.
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- Chen, Aoxue (författare)
- Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
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- Liu, Hao-Yu (författare)
- Yangzhou Univ, Dept Anim Nutr, Coll Anim Sci & Technol, Yangzhou, Jiangsu, Peoples R China.;Yangzhou Univ, Epigenet & Epigenome Res Inst, Yangzhou, Jiangsu, Peoples R China.
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(creator_code:org_t)
- 2021-08-06
- 2021
- Engelska.
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Ingår i: Frontiers in Nutrition. - : Frontiers Media S.A.. - 2296-861X. ; 8
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Inflammatory bowel disease (IBD) is a recurrent chronic inflammatory condition of the intestine without any efficient therapeutic regimens. Gut microbiota, which plays an instrumental role in the development and maturation of the immune system, has been implicated in the pathogenesis of IBD. Emerging evidence has established that early-life events particularly maternal influences and antibiotic treatment are strongly correlated with the health or susceptibility to disease of an individual in later life. Thus, it is proposed that there is a critical period in infancy, during which the environmental exposures bestow a long-term pathophysiological imprint. This notion sheds new light on the development of novel approaches for the treatment, i.e., early interventions, more precisely, the prevention of many uncurable chronic inflammatory diseases like IBD. In this review, we have integrated current evidence to describe the feasibility of the "able-to-be-regulated microbiota," summarized the underlying mechanisms of the "microbiota-driven immune system education," explored the optimal intervention time window, and discussed the potential of designing early-probiotic treatment as a new prevention strategy for IBD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- early-life intervention
- gut microbiota
- probiotics
- weaning
- inflammatory bowel disease
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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