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Genomic insights into population history and biological adaptation in Oceania

Choin, Jeremy (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France.
Mendoza-Revilla, Javier (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.
Arauna, Lara R. (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.
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Cuadros-Espinoza, Sebastian (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.;Sorbonne Univ, Coll Doctoral, Paris, France.
Cassar, Olivier (författare)
Inst Pasteur, CNRS, Oncogen Virus Epidemiol & Pathophysiol, UMR 3569, Paris, France.
Larena, Maximilian (författare)
Uppsala universitet,Människans evolution
Ko, Albert Min-Shan (författare)
Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China.
Harmant, Christine (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.
Laurent, Romain (författare)
Univ Paris, CNRS, UMR7206, Museum Natl Hist Nat, Paris, France.
Verdu, Paul (författare)
Univ Paris, CNRS, UMR7206, Museum Natl Hist Nat, Paris, France.
Laval, Guillaume (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.
Boland, Anne (författare)
Univ Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, Inst Biol Francois Jacob, CEA, Evry, France.
Olaso, Robert (författare)
Univ Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, Inst Biol Francois Jacob, CEA, Evry, France.
Deleuze, Jean-Francois (författare)
Univ Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, Inst Biol Francois Jacob, CEA, Evry, France.
Valentin, Frederique (författare)
CNRS, UMR 7041, Maison Archeol & Ethnol, Nanterre, France.
Ko, Ying-Chin (författare)
China Med Univ & Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan.
Jakobsson, Mattias (författare)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Människans evolution
Gessain, Antoine (författare)
Inst Pasteur, CNRS, Oncogen Virus Epidemiol & Pathophysiol, UMR 3569, Paris, France.
Excoffier, Laurent (författare)
Univ Bern, Inst Ecol & Evolut, Bern, Switzerland.;Swiss Inst Bioinformat, Lausanne, Switzerland.
Stoneking, Mark (författare)
Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig, Germany.
Patin, Etienne (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.
Quintana-Murci, Lluis (författare)
Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.;Coll France, Paris, France.
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Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France. Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France. (creator_code:org_t)
2021-04-14
2021
Engelska.
Ingår i: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 592:7855, s. 583-589
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The Pacific region is of major importance for addressing questions regarding human dispersals, interactions with archaic hominins and natural selection processes(1). However, the demographic and adaptive history of Oceanian populations remains largely uncharacterized. Here we report high-coverage genomes of 317 individuals from 20 populations from the Pacific region. We find that the ancestors of Papuan-related ('Near Oceanian') groups underwent a strong bottleneck before the settlement of the region, and separated around 20,000-40,000 years ago. We infer that the East Asian ancestors of Pacific populations may have diverged from Taiwanese Indigenous peoples before the Neolithic expansion, which is thought to have started from Taiwan around 5,000 years ago(2-4). Additionally, this dispersal was not followed by an immediate, single admixture event with Near Oceanian populations, but involved recurrent episodes of genetic interactions. Our analyses reveal marked differences in the proportion and nature of Denisovan heritage among Pacific groups, suggesting that independent interbreeding with highly structured archaic populations occurred. Furthermore, whereas introgression of Neanderthal genetic information facilitated the adaptation of modern humans related to multiple phenotypes (for example, metabolism, pigmentation and neuronal development), Denisovan introgression was primarily beneficial for immune-related functions. Finally, we report evidence of selective sweeps and polygenic adaptation associated with pathogen exposure and lipid metabolism in the Pacific region, increasing our understanding of the mechanisms of biological adaptation to island environments.

Ämnesord

NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)

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