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Central sensitisation in chronic pain conditions : latest discoveries and their potential for precision medicine

Nijs, Jo (författare)
Vrije Univ Brussel, Fac Phys Educ & Physiotherapy, Dept Physiotherapy Human Physiol & Anat, Pain Mot Res Grp, BE-1090 Brussels, Belgium.;Univ Hosp Brussels, Dept Phys Med & Physiotherapy, Chron Pain Rehabil, Brussels, Belgium.;Univ Gothenburg, Dept Hlth & Rehabil, Unit Physiotherapy, Inst Neurosci & Physiol, Gothenburg, Sweden.;Univ Gothenburg, Ctr Person Centred Care GPCC, Gothenburg, Sweden.
George, Steven Z. (författare)
Duke Univ, Dept Orthopaed Surg, Durham, NC USA.;Duke Univ, Duke Clin Res Inst, Durham, NC USA.
Clauw, Daniel J. (författare)
Univ Michigan, Chron Pain & Fatigue Res Ctr, Dept Anesthesiol, Ann Arbor, MI 48109 USA.
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Fernandez-de-las-Penas, Cesar (författare)
Univ Rey Juan Carlos, Dept Phys Therapy Occupat Therapy Phys Med & Reha, Madrid, Spain.
Kosek, Eva (författare)
Karolinska Institutet,Uppsala universitet,Klinisk smärtforskning,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
Ickmans, Kelly (författare)
Vrije Univ Brussel, Fac Phys Educ & Physiotherapy, Dept Physiotherapy Human Physiol & Anat, Pain Mot Res Grp, BE-1090 Brussels, Belgium.;Univ Hosp Brussels, Dept Phys Med & Physiotherapy, Chron Pain Rehabil, Brussels, Belgium.;Res Fdn Flanders FWO, Brussels, Belgium.
Fernandez-Carnero, Josue (författare)
Univ Rey Juan Carlos, Dept Phys Therapy Occupat Therapy Phys Med & Reha, Madrid, Spain.
Polli, Andrea (författare)
Vrije Univ Brussel, Fac Phys Educ & Physiotherapy, Dept Physiotherapy Human Physiol & Anat, Pain Mot Res Grp, BE-1090 Brussels, Belgium.;Res Fdn Flanders FWO, Brussels, Belgium.
Kapreli, Eleni (författare)
Univ Thessaly, Fac Hlth Sci, Physiotherapy Dept, Clin Exercise Physiol & Rehabil Res Lab, Lamia, Greece.
Huysmans, Eva (författare)
Vrije Univ Brussel, Fac Phys Educ & Physiotherapy, Dept Physiotherapy Human Physiol & Anat, Pain Mot Res Grp, BE-1090 Brussels, Belgium.;Univ Hosp Brussels, Dept Phys Med & Physiotherapy, Chron Pain Rehabil, Brussels, Belgium.;Res Fdn Flanders FWO, Brussels, Belgium.
Cuesta-Vargas, Antonio, I (författare)
Univ Malaga Andalucia Tech, Catedra Fisioterapia, Inst Invest Biomed Malaga IBIMA, Grp Clin F14, Malaga, Spain.
Mani, Ramakrishnan (författare)
Univ Otago, Ctr Hlth Activ & Rehabil Res, Sch Physiotherapy & Pain Otago Res Theme, Dunedin, New Zealand.
Lundberg, Mari (författare)
Univ Gothenburg, Dept Hlth & Rehabil, Unit Physiotherapy, Inst Neurosci & Physiol, Gothenburg, Sweden.;Univ Gothenburg, Ctr Person Centred Care GPCC, Gothenburg, Sweden.
Leysen, Laurence (författare)
Vrije Univ Brussel, Fac Phys Educ & Physiotherapy, Dept Physiotherapy Human Physiol & Anat, Pain Mot Res Grp, BE-1090 Brussels, Belgium.
Rice, David (författare)
Auckland Univ Technol, Sch Clin Sci, Hlth & Rehabil Res Inst, Auckland, New Zealand.;Waitemata Dist Hlth Board, Dept Anaesthesiol & Perioperat Med, Auckland, New Zealand.
Sterling, Michele (författare)
Univ Queensland, Recover Injury Res Ctr, Brisbane, Qld, Australia.;Univ Queensland, NHMRC Ctr Res Excellence Recovery Following Rd Tr, Brisbane, Qld, Australia.
Curatolo, Michele (författare)
Univ Washington, CLEAR Ctr Musculoskeletal Disorders, Harborview Injury Prevent & Res Ctr, Seattle, WA USA.;Univ Washington, Dept Anesthesiol & Pain Med, Sch Med, Seattle, WA USA.
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Vrije Univ Brussel, Fac Phys Educ & Physiotherapy, Dept Physiotherapy Human Physiol & Anat, Pain Mot Res Grp, BE-1090 Brussels, Belgium;Univ Hosp Brussels, Dept Phys Med & Physiotherapy, Chron Pain Rehabil, Brussels, Belgium.;Univ Gothenburg, Dept Hlth & Rehabil, Unit Physiotherapy, Inst Neurosci & Physiol, Gothenburg, Sweden.;Univ Gothenburg, Ctr Person Centred Care GPCC, Gothenburg, Sweden. Duke Univ, Dept Orthopaed Surg, Durham, NC USA.;Duke Univ, Duke Clin Res Inst, Durham, NC USA. (creator_code:org_t)
Elsevier, 2021
2021
Engelska.
Ingår i: The Lancet Rheumatology. - : Elsevier. - 2665-9913. ; 3:5, s. E383-E392
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms represents a diagnostic challenge for rheumatology specialists. Central sensitisation, defined as an amplification of neural signalling within the CNS that elicits pain hypersensitivity, has been investigated as a reason for this discrepancy. Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spinal pain. Within individual pain conditions, there is substantial variation among patients in terms of presence and magnitude of central sensitisation, stressing the importance of individual assessment. Central sensitisation predicts poor treatment outcomes in multiple patient populations. The available evidence supports various pharmacological and non-pharmacological strategies to reduce central sensitisation and to improve patient outcomes in several conditions commonly seen in rheumatology practice. These data open up new treatment perspectives, with the possibility for precision pain medicine treatment according to pain phenotyping as a logical next step. With this view, studies suggest the possibility of matching non-pharmacological approaches, or medications, or both to the central sensitisation pain

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

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