Search: id:"swepub:oai:DiVA.org:uu-456305" >
Fecal Short-Chain F...
Fecal Short-Chain Fatty Acid Ratios as Related to Gastrointestinal and Depressive Symptoms in Young Adults
-
- Müller, Bettina (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Swedish Univ Agr Sci, Dept Mol Sci, Bioctr, Uppsala, Sweden.
-
- Rasmusson, Annica J. (author)
- Uppsala universitet,Cervenka: Psykiatri,Uppsala Univ Hosp, Dept Neurosci, Psychiat, SE-75185 Uppsala, Sweden.
-
- Just, David (author)
- Uppsala Univ Hosp, Dept Neurosci, Psychiat, SE-75185 Uppsala, Sweden.
-
show more...
-
- Jayarathna, Shishanthi (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Swedish Univ Agr Sci, Dept Mol Sci, Bioctr, Uppsala, Sweden.
-
- Moazzami, Ali (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Swedish Univ Agr Sci, Dept Mol Sci, Bioctr, Uppsala, Sweden.
-
- Novicic, Zorana Kurbalija (author)
- Uppsala Univ Hosp, Dept Neurosci, Psychiat, SE-75185 Uppsala, Sweden.
-
- Cunningham, Janet (author)
- Uppsala universitet,Cervenka: Psykiatri,Uppsala Univ Hosp, Dept Neurosci, Psychiat, SE-75185 Uppsala, Sweden.
-
show less...
-
(creator_code:org_t)
-
- Wolters Kluwer, 2021
- 2021
- English.
-
In: Psychosomatic Medicine. - : Wolters Kluwer. - 0033-3174 .- 1534-7796. ; 83:7, s. 693-699
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://pub.epsilon.... (primary) (Raw object) (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://res.slu.se/i...
-
show less...
Abstract
Subject headings
Close
- Objective: Short-chain fatty acids (SCFAs) are produced by the gut microbiota and may reflect health. Gut symptoms are common in individuals with depressive disorders, and recent data indicate relationships between gut microbiota and psychiatric health. We aimed to investigate potential associations between SCFAs and self-reported depressive and gut symptoms in young adults. Methods: Fecal samples from 164 individuals (125 were patients with psychiatric disorders: mean [standard deviation] age = 21.9 [2.6] years, 14% men; 39 nonpsychiatric controls: age = 28.5 [9.5] years, 38% men) were analyzed for the SCFA acetate, butyrate, and propionate by nuclear magnetic resonance spectroscopy. We then compared SCFA ratios with dimensional measures of self-reported depressive and gut symptoms. Results: Depressive symptoms showed a positive association with acetate levels (rho = 0.235, p =.003) and negative associations with both butyrate (rho = -0.195, p =.014) and propionate levels (rho = -0.201, p =.009) in relation to total SCFA levels. Furthermore, symptoms of diarrhea showed positive associations with acetate (rho = 0.217, p =.010) and negative associations with propionate in relation to total SCFA levels (rho = 0.229, p = 0-007). Cluster analysis revealed a heterogeneous pattern where shifts in SCFA ratios were observed in individuals with elevated levels of depressive symptoms, elevated levels of gut symptoms, or both. Conclusions: Shifts in SCFAs are associated with both depressive symptoms and gut symptoms in young adults and may have of relevance for treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- depressive disorders
- gut microbiota
- NMR
- SCFA
- gut symptoms
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database