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Exploring the assoc...
Exploring the association between use of gonadotropin releasing hormones agonists and prostate cancer diagnosis per se and diabetes control in men with type 2 diabetes mellitus : a nationwide, population-based cohort study
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- Lin, E. (författare)
- Kings Coll London, Guys Hosp, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, 3rd Floor Bermondsey Wing, London SE1 9RT, England.
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- Garmo, Hans (författare)
- Kings Coll London, Guys Hosp, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, 3rd Floor Bermondsey Wing, London SE1 9RT, England.
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- Van Hemelrijck, Mieke (författare)
- Kings Coll London, Guys Hosp, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, 3rd Floor Bermondsey Wing, London SE1 9RT, England.
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- Adolfsson, Jan (författare)
- Karolinska Institutet
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- Stattin, Pär (författare)
- Uppsala universitet,Urologkirurgi
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- Zethelius, Björn (författare)
- Uppsala universitet,Geriatrik,Uppsala Univ, Dept Publ Hlth Geriatr, Uppsala, Sweden.
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- Crawley, Danielle (författare)
- Kings Coll London, Guys Hosp, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, 3rd Floor Bermondsey Wing, London SE1 9RT, England.
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Karolinska Institutet Kings Coll London, Guys Hosp, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, 3rd Floor Bermondsey Wing, London SE1 9RT, England (creator_code:org_t)
- 2021-11-22
- 2021
- Engelska.
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Ingår i: BMC Cancer. - : BioMed Central (BMC). - 1471-2407. ; 21:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://bmccancer.bi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Gonadotropin Releasing Hormones agonists (GnRH), which are first line treatment for metastatic prostate cancer (PCa), increase risk of type 2 diabetes mellitus (T2DM). This study aims to quantify the association of use of GnRH with diabetes control in PCa men with T2DM. Methods Nationwide population-based cohort study in the Swedish National Diabetes Register and Prostate Cancer data Base Sweden 4.1, on the association between GnRH and diabetes control in T2DM men with PCa by comparing T2DM men with PCa vs. without PCa, as well as comparing T2DM men with PCa on or not on GnRH. The primary exposure was use of GnRH. Worsening diabetes control was the primary outcome, defined as: 1) HbA1c rose to 58 mmol/mol or higher; 2) HbA1c increase by 10 mmol/mol or more; 3) Start of antidiabetic drugs or switch to insulin. We also combined all above definitions. Cox proportional hazards regression was used to analyze the association. Results There were 5714 T2DM men with PCa of whom 692 were on GnRH and 28,445 PCa-free men with T2DM with similar baseline characteristics. Diabetes control was worse in men with GnRH vs. PCa-free men (HR: 1.24, 95% CI: 1.13-1.34) as well as compared with PCa men without GnRH (HR:1.58, 95% CI: 1.39-1.80), when we defined the worsening control of diabetes by combining all definitions above. Conclusion Use of GnRH in T2DM men with PCa was associated with worse glycemic control. The findings highlight the need to closely monitor diabetes control in men with T2DM and PCa starting GnRH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Prostate cancer diagnosis
- Gonadotropin-releasing hormone agonists
- Diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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