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Four Systemic Lupus...
Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations
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- Diaz-Gallo, Lina-Marcela (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Oke, Vilija (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Lundström, Emeli (författare)
- Karolinska University Hospital
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- Elvin, Kerstin (författare)
- Karolinska University Hospital
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- Ling Wu, Yee (författare)
- Loyola University Chicago
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- Eketjäll, Susanna (författare)
- AstraZeneca, Sweden
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- Zickert, Agneta (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Gustafsson, Johanna T (författare)
- Karolinska University Hospital
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Leonard, Dag, 1975- (författare)
- Uppsala University,Uppsala universitet,Reumatologi
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- Birmingham, Daniel J (författare)
- Ohio State University
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- Nordmark, Gunnel (författare)
- Uppsala University,Uppsala universitet,Reumatologi
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- Bengtsson, Anders A. (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Rönnblom, Lars (författare)
- Uppsala University,Uppsala universitet,Reumatologi
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- Gunnarsson, Iva (författare)
- Karolinska Institutet,Karolinska University Hospital
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Yu, Chack-Yung (författare)
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- Padyukov, Leonid (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Svenungsson, Elisabet (författare)
- Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- 2021-10-17
- 2022
- Engelska.
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Ingår i: ACR Open Rheumatology. - : John Wiley & Sons. - 2578-5745. ; 4:1, s. 27-39
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://onlinelibrar...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective: The heterogeneity of systemic lupus erythematosus (SLE) constitutes clinical and therapeutical challenges. We therefore studied whether unrecognized disease subgroups can be identified by using autoantibody profiling together with HLA-DRB1 alleles and immunological and clinical data.Methods: An unsupervised cluster analysis was performed based on detection of 13 SLE-associated autoantibodies (double-stranded DNA, nucleosomes, ribosomal P, ribonucleoprotein [RNP] 68, RNPA, Smith [Sm], Sm/RNP, Sjögren's syndrome antigen A [SSA]/Ro52, SSA/Ro60, Sjögren's syndrome antigen B [SSB]/La, cardiolipin [CL]-Immunoglobulin G [IgG], CL-Immunoglobulin M [IgM], and β2 glycoprotein I [β2 GPI]-IgG) in 911 patients with SLE from two cohorts. We evaluated whether each SLE subgroup is associated with HLA-DRB1 alleles, clinical manifestations (n = 743), and cytokine levels in circulation (n = 446).Results: Our analysis identified four subgroups among the patients with SLE. Subgroup 1 (29.3%) was dominated by anti-SSA/Ro60/Ro52/SSB autoantibodies and was strongly associated with HLA-DRB1*03 (odds ratio [OR] = 4.73; 95% confidence interval [CI] = 4.52-4.94). Discoid lesions were more common for this disease subgroup (OR = 1.71, 95% CI = 1.18-2.47). Subgroup 2 (28.7%) was dominated by anti-nucleosome/SmRNP/DNA/RNPA autoantibodies and associated with HLA-DRB1*15 (OR = 1.62, 95% CI = 1.41-1.84). Nephritis was most common in this subgroup (OR = 1.61, 95% CI = 1.14-2.26). Subgroup 3 (23.8%) was characterized by anti-ß2 GPI-IgG/anti-CL-IgG/IgM autoantibodies and a higher frequency of HLA-DRB1*04 compared with the other patients with SLE. Vascular events were more common in Subgroup 3 (OR = 1.74, 95% CI = 1.2-2.5). Subgroup 4 (18.2%) was negative for the investigated autoantibodies, and this subgroup was not associated with HLA-DRB1. Additionally, the levels of eight cytokines significantly differed among the disease subgroups.Conclusion: Our findings suggest that four fairly distinct subgroups can be identified on the basis of the autoantibody profile in SLE. These four SLE subgroups differ regarding associations with HLA-DRB1 alleles and immunological and clinical features, suggesting dissimilar disease pathways.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (ämneskategori)
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Diaz-Gallo, Lina ...
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Oke, Vilija
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Lundström, Emeli
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Elvin, Kerstin
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Ling Wu, Yee
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Eketjäll, Susann ...
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visa fler...
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Zickert, Agneta
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Gustafsson, Joha ...
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Jönsen, Andreas
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Leonard, Dag, 19 ...
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Birmingham, Dani ...
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Nordmark, Gunnel
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Bengtsson, Ander ...
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Rönnblom, Lars
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Gunnarsson, Iva
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Yu, Chack-Yung
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Padyukov, Leonid
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Svenungsson, Eli ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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ACR Open Rheumat ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet