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Plasma Proteome Fin...
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection
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- Bauer, Wolfgang (författare)
- Charite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
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- Weber, Marcus (författare)
- Zuse Inst Berlin ZIB, Takustr 7, D-14195 Berlin, Germany.
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- Diehl-Wiesenecker, Eva (författare)
- Charite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
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- Galtung, Noa (författare)
- Charite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
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- Prpic, Monika (författare)
- Free Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.
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- Somasundaram, Rajan (författare)
- Charite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
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- Tauber, Rudolf (författare)
- Free Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.;Labor Berlin Charite Vivantes GmbH, D-13353 Berlin, Germany.
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- Schwenk, Jochen M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Tomtebodavagen 23, S-17165 Solna, Sweden.
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- Micke, Patrick (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Uppsala Univ, Dept Immunol Genet & Pathol, Dag Hammarskjolds Vag 20, S-75185 Uppsala, Sweden.
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- Kappert, Kai (författare)
- Free Univ Berlin, Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochem, Augustenburger Pl 1, D-13353 Berlin, Germany.;Labor Berlin Charite Vivantes GmbH, D-13353 Berlin, Germany.
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Charite Univ Med Berlin, Dept Emergency Med, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany Zuse Inst Berlin ZIB, Takustr 7, D-14195 Berlin, Germany. (creator_code:org_t)
- 2021-12-07
- 2021
- Engelska.
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Ingår i: Viruses. - : MDPI. - 1999-4915. ; 13:12
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: We evaluated how plasma proteomic signatures in patients with suspected COVID-19 can unravel the pathophysiology, and determine kinetics and clinical outcome of the infection.Methods: Plasma samples from patients presenting to the emergency department (ED) with symptoms of COVID-19 were stratified into: (1) patients with suspected COVID-19 that was not confirmed (n = 44); (2) non-hospitalized patients with confirmed COVID-19 (n = 44); (3) hospitalized patients with confirmed COVID-19 (n = 53) with variable outcome; and (4) patients presenting to the ED with minor diseases unrelated to SARS-CoV-2 infection (n = 20). Besides standard of care diagnostics, 177 circulating proteins related to inflammation and cardiovascular disease were analyzed using proximity extension assay (PEA, Olink) technology.Results: Comparative proteome analysis revealed 14 distinct proteins as highly associated with SARS-CoV-2 infection and 12 proteins with subsequent hospitalization (p < 0.001). ADM, IL-6, MCP-3, TRAIL-R2, and PD-L1 were each predictive for death (AUROC curve 0.80-0.87). The consistent increase of these markers, from hospital admission to intensive care and fatality, supported the concept that these proteins are of major clinical relevance.Conclusions: We identified distinct plasma proteins linked to the presence and course of COVID-19. These plasma proteomic findings may translate to a protein fingerprint, helping to assist clinical management decisions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- COVID-19
- proteomics
- risk prediction
- proximity extension assay
- emergency medicine
- Pathology
- Patologi
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- ref (ämneskategori)
- art (ämneskategori)
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