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Sökning: id:"swepub:oai:DiVA.org:uu-464451" > Kel1 is a phosphory...

Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway

Garcia, Ignacio (författare)
Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.
Orellana-Munoz, Sara (författare)
Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.
Ramos-Alonso, Lucia (författare)
Univ Oslo, Fac Math & Nat Sci, Sect Biochem & Mol Biol, N-0316 Oslo, Norway.;Oslo Univ Hosp, Dept Microbiol, N-0372 Oslo, Norway.
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Andersen, Aram N. (författare)
Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Univ Oslo, Fac Math & Nat Sci, Sect Biochem & Mol Biol, N-0316 Oslo, Norway.
Zimmermann, Christine (författare)
Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Virol, D-55131 Mainz, Germany.
Eriksson, Jens, 1982- (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
Bøe, Stig Ove (författare)
Oslo Univ Hosp, Dept Microbiol, N-0372 Oslo, Norway.
Kaferle, Petra (författare)
Sorbonne Univ, PSL Res Univ, Inst Curie, CNRS,UMR3664, Paris, France.
Papamichos-Chronakis, Manolis (författare)
Univ Liverpool, Dept Mol Physiol, Liverpool L69 7BE, Merseyside, England.;Univ Liverpool, Cell Signalling Inst Syst Mol & Integrat Biol, Liverpool L69 7BE, Merseyside, England.
Chymkowitch, Pierre (författare)
Univ Oslo, Fac Math & Nat Sci, Sect Biochem & Mol Biol, N-0316 Oslo, Norway.;Oslo Univ Hosp, Dept Microbiol, N-0372 Oslo, Norway.
Enserink, Jorrit M. (författare)
Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Univ Oslo, Fac Math & Nat Sci, Sect Biochem & Mol Biol, N-0316 Oslo, Norway.
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Norwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, N-0379 Oslo, Norway;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway. Univ Oslo, Fac Math & Nat Sci, Sect Biochem & Mol Biol, N-0316 Oslo, Norway.;Oslo Univ Hosp, Dept Microbiol, N-0372 Oslo, Norway. (creator_code:org_t)
Elsevier, 2021
2021
Engelska.
Ingår i: Cell Reports. - : Elsevier. - 2211-1247. ; 37:13
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
http://www.cell.com/...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Mechanisms have evolved that allow cells to detect signals and generate an appropriate response. The accuracy of these responses relies on the ability of cells to discriminate between signal and noise. How cells filter noise in signaling pathways is not well understood. Here, we analyze noise suppression in the yeast pheromone signaling pathway and show that the poorly characterized protein Kel1 serves as a major noise suppressor and prevents cell death. At the molecular level, Kel1 prevents spontaneous activation of the pheromone response by inhibiting membrane recruitment of Ste5 and Far1. Only a hypophosphorylated form of Kel1 suppresses signaling, reduces noise, and prevents pheromone-associated cell death, and our data indicate that the MAPK Fus3 contributes to Kel1 phosphorylation. Taken together, Kel1 serves as a phosphoregulated suppressor of the pheromone pathway to reduce noise, inhibit spontaneous activation of the pathway, regulate mating efficiency, and prevent pheromone-associated cell death.

Ämnesord

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)

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