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T1-Weighted/T2-Weig...
T1-Weighted/T2-Weighted Ratio Mapping at 5 Months Captures Individual Differences in Behavioral Development and Differentiates Infants at Familial Risk for Autism from Controls
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- Darki, Fahimeh (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Ctr Psychiat Res, Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, SE-11330 Stockholm, Sweden.;Stockholm Hlth Care Serv, SE-11330 Stockholm, Region Stockhol, Sweden.
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- Nyström, Pär, 1975- (författare)
- Uppsala universitet,Institutionen för psykologi
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- McAlonan, Grainne (författare)
- Kings Coll London, South London & Maudsley NHS Fdn Trust, Inst Psychiat Psychol & Neurosci, Sackler Inst, London WC2R 2LS, England.;Kings Coll London, South London & Maudsley NHS Fdn Trust, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, London WC2R 2LS, England.
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- Bölte, Sven (författare)
- Karolinska Institutet,Karolinska Inst, Ctr Psychiat Res, Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, SE-11330 Stockholm, Sweden.;Stockholm Hlth Care Serv, SE-11330 Stockholm, Region Stockhol, Sweden.;Stockholm Hlth Care Serv, Child & Adolescent Psychiat, Stockholm, Region Stockhol, Sweden.;Curtin Univ, Sch Occupat Therapy Social Work & Speech Pathol, Curtin Autism Res Grp, Perth, WA 6102, Australia.
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- Falck-Ytter, Terje (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Kollegiet för avancerade studier (SCAS),Karolinska Inst, Ctr Psychiat Res, Ctr Neurodev Disorders KIND, Dept Womens & Childrens Hlth, SE-11330 Stockholm, Sweden.;Stockholm Hlth Care Serv, SE-11330 Stockholm, Region Stockhol, Sweden.
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(creator_code:org_t)
- 2021-04-07
- 2021
- Engelska.
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Ingår i: Cerebral Cortex. - : Oxford University Press. - 1047-3211 .- 1460-2199. ; 31:9, s. 4068-4077
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Identifying structural measures that capture early brain development and are sensitive to individual differences in behavior is a priority in developmental neuroscience, with potential implications for our understanding of both typical and atypical populations. T1-weighted/T2-weighted (T1w/T2w) ratio mapping, which previously has been linked to myelination, represents an interesting candidate measure in this respect, as an accessible measure from standard magnetic resonance imaging (MRI) sequences. Yet, its value as an early infancy measure remains largely unexplored. Here, we compared T1w/T2w ratio in 5-month-old infants at familial risk (n = 27) for autism spectrum disorder (ASD) to those without elevated autism risk (n =16). We found lower T1w/T2w ratio in infants at high risk for ASD within widely distributed regions, spanning both white and gray matter. In regions differing between groups, higher T1w/T2w ratio was robustly associated with higher age at scan (range: similar to 4-6.5 months), implying sensitivity to maturation at short developmental timescales. Further, higher T1w/T2w ratio within these regions was associated with higher scores on measures of concurrent developmental level. These findings suggest that T1w/T2w ratio is a developmentally sensitive measure that should be explored further in future studies of both typical and atypical infant populations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- biomarker
- brain
- early detection
- infants
- MRI
- myelination
- risk
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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