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The feather pattern...
The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus
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- Schwochow, Doreen (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden.;Univ Paris Saclay, INRAE, AgroParisTech, GABI, Jouy En Josas, France.,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,National Research Institute for Agriculture, Food and Environment (INRAE)
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- Bornelöv, Susanne, 1984- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England.
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- Jiang, Tingxing (author)
- Univ Southern Calif, Dept Pathol, Los Angeles, CA 90007 USA.
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- Li, Jingyi (author)
- Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA USA.;Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX USA.
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- Gourichon, David (author)
- INRAE, PEAT, Nouzilly, France.
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- Bed'Hom, Bertrand (author)
- Univ Paris Saclay, INRAE, AgroParisTech, GABI, Jouy En Josas, France.
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- Dorshorst, Ben J. (author)
- Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA USA.
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- Chuong, Cheng-Ming (author)
- Univ Southern Calif, Dept Pathol, Los Angeles, CA 90007 USA.
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- Tixier-Boichard, Michele (author)
- Univ Paris Saclay, INRAE, AgroParisTech, GABI, Jouy En Josas, France.
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden.;Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX USA.,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University
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(creator_code:org_t)
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- 2021-05-04
- 2021
- English.
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In: Pigment Cell & Melanoma Research. - : John Wiley & Sons. - 1755-1471 .- 1755-148X. ; 34:6, s. 1015-1028
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Abstract
Subject headings
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- Color patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual feathers. Using an informative backcross, we demonstrate that the MC1R locus is strongly associated with this phenotype. A deletion at SOX10, underlying the dark brown phenotype on its own, affects the manifestation of the barring pattern. The coding variant L133Q in MC1R is the most likely causal mutation for autosomal barring in this pedigree. Furthermore, a genetic screen across six different breeds showing different patterning phenotypes revealed that the most striking shared characteristics among these breeds were that they all carried the MC1R alleles Birchen or brown. Our data suggest that the presence of activating MC1R mutations enhancing pigment synthesis is an important mechanism underlying pigmentation patterns on individual feathers in chicken. We propose that MC1R and its antagonist ASIP play a critical role for determining within-feather pigmentation patterns in birds by acting as activator and inhibitor possibly in a Turing reaction-diffusion model.
Subject headings
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience -- Animal and Dairy Science. (hsv//eng)
Keyword
- chicken
- feather patterning
- genetics
- MC1R
- pigmentation
- SOX10
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schwochow, Doree ...
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Bornelöv, Susann ...
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Jiang, Tingxing
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Li, Jingyi
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Gourichon, David
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Bed'Hom, Bertran ...
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show more...
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Dorshorst, Ben J ...
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Chuong, Cheng-Mi ...
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Tixier-Boichard, ...
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Andersson, Leif
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- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Genetics and Bre ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Animal and Dairy ...
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and Animal and Dairy ...
- Articles in the publication
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Pigment Cell & M ...
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences