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Selenium and cancer...
Selenium and cancer risk : Wide-angled Mendelian randomization analysis
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- Yuan, Shuai (författare)
- Karolinska Institutet,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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- Mason, Amy M. (författare)
- Univ Cambridge, British Heart Fdn Cardiovasc Epidemiol Unit, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Natl Inst Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.;Cambridge Univ Hosp, Cambridge, England.
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- Carter, Paul (författare)
- Univ Cambridge, Dept Med, Cambridge, England.
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- Vithayathil, Mathew (författare)
- Univ Cambridge, MRC Canc Unit, Cambridge, England.
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- Kar, Siddhartha (författare)
- Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.
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- Burgess, Stephen (författare)
- Univ Cambridge, MRC Biostat Unit, Cambridge, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Medicinsk epidemiologi,Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.;Uppsala Univ, Dept Surg Sci, Unit Med Epidemiol, Uppsala, Sweden.
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Karolinska Institutet Inst Environm Med, Karolinska Inst, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden (creator_code:org_t)
- 2021-12-24
- 2022
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 150:7, s. 1134-1140
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Abstract
Ämnesord
Stäng
- Evidence on the association between selenium and cancer risk is inconclusive. We conducted a Mendelian randomization study to examine the associations of selenium levels with 22 site-specific cancers and any cancer. Single nucleotide polymorphisms (SNPs) strongly associated with toenail and blood (TAB) and blood selenium levels in mild linkage disequilibrium (r(2) < .3) were used as instrumental variables. Genetic associations of selenium-associated SNPs with cancer were obtained from the UK Biobank including a total of 59 647 cancer cases and 307 914 controls. Associations with P < .1 in UK Biobank were tested for replication in the FinnGen consortium comprising more than 180 000 individuals. The inverse-variance weighted method accounting for linkage disequilibrium was used to estimate the associations. Genetically predicted TAB selenium levels were not associated with the risk of the 22 site-specific cancers or any cancer (all 22 site-specific cancers). Similarly, we observed no strong association for genetically predicted blood selenium levels. However, genetically predicted blood selenium levels showed suggestive associations with risk of kidney cancer (odds ratio [OR] per one-unit increase in log-transformed levels: 0.83; 95% confidence interval [CI]: 0.67-1.03) and multiple myeloma (OR: 1.40; 95% CI: 1.02-1.93). The same direction of association for kidney cancer but not for multiple myeloma was observed in FinnGen. In the metaanalysis of UK Biobank and FinnGen, the OR of kidney cancer was 0.83 (95% CI: 0.69-1.00). Our study suggests that high selenium status may not prevent cancer development. The associations for kidney cancer and multiple myeloma need to be verified in well-powered studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cancer
- kidney cancer
- Mendelian randomization
- selenium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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