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Genetic and Epigene...
Genetic and Epigenetic Markers of Lithium Response
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- Pisanu, Claudia (författare)
- Uppsala universitet,Schiöth: Funktionell farmakologi,Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.;Uppsala Univ, Sect Funct Pharmacol & Neurosci, Dept Surg Sci, S-75124 Uppsala, Sweden.
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- Meloni, Anna (författare)
- Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.
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- Severino, Giovanni (författare)
- Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.
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- Squassina, Alessio (författare)
- Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.;Dalhousie Univ, Dept Psychiat, Fac Med, Halifax, NS B3H 2E2, Canada.
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(creator_code:org_t)
- 2022-01-29
- 2022
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:3, s. 1555-
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The mood stabilizer lithium represents a cornerstone in the long term treatment of bipolar disorder (BD), although with substantial interindividual variability in clinical response. This variability appears to be modulated by genetics, which has been significantly investigated in the last two decades with some promising findings. In addition, recently, the interest in the role of epigenetics has grown significantly, since the exploration of these mechanisms might allow the elucidation of the gene-environment interactions and explanation of missing heritability. In this article, we provide an overview of the most relevant findings regarding the pharmacogenomics and pharmacoepigenomics of lithium response in BD. We describe the most replicated findings among candidate gene studies, results from genome-wide association studies (GWAS) as well as post-GWAS approaches supporting an association between high genetic load for schizophrenia, major depressive disorder or attention deficit/hyperactivity disorder and poor lithium response. Next, we describe results from studies investigating epigenetic mechanisms, such as changes in methylation or noncoding RNA levels, which play a relevant role as regulators of gene expression. Finally, we discuss challenges related to the search for the molecular determinants of lithium response and potential future research directions to pave the path towards a biomarker guided approach in lithium treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- lithium
- pharmacogenomics
- pharmacogenetics
- biomarker
- personalized medicine
- precision medicine
- GWAS
- methylation
- epigenetic
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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