SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:uu-469062"
 

Sökning: id:"swepub:oai:DiVA.org:uu-469062" > Genetic and Epigene...

Genetic and Epigenetic Markers of Lithium Response

Pisanu, Claudia (författare)
Uppsala universitet,Schiöth: Funktionell farmakologi,Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.;Uppsala Univ, Sect Funct Pharmacol & Neurosci, Dept Surg Sci, S-75124 Uppsala, Sweden.
Meloni, Anna (författare)
Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.
Severino, Giovanni (författare)
Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.
visa fler...
Squassina, Alessio (författare)
Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, I-09042 Cagliari, Italy.;Dalhousie Univ, Dept Psychiat, Fac Med, Halifax, NS B3H 2E2, Canada.
visa färre...
 (creator_code:org_t)
2022-01-29
2022
Engelska.
Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:3, s. 1555-
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The mood stabilizer lithium represents a cornerstone in the long term treatment of bipolar disorder (BD), although with substantial interindividual variability in clinical response. This variability appears to be modulated by genetics, which has been significantly investigated in the last two decades with some promising findings. In addition, recently, the interest in the role of epigenetics has grown significantly, since the exploration of these mechanisms might allow the elucidation of the gene-environment interactions and explanation of missing heritability. In this article, we provide an overview of the most relevant findings regarding the pharmacogenomics and pharmacoepigenomics of lithium response in BD. We describe the most replicated findings among candidate gene studies, results from genome-wide association studies (GWAS) as well as post-GWAS approaches supporting an association between high genetic load for schizophrenia, major depressive disorder or attention deficit/hyperactivity disorder and poor lithium response. Next, we describe results from studies investigating epigenetic mechanisms, such as changes in methylation or noncoding RNA levels, which play a relevant role as regulators of gene expression. Finally, we discuss challenges related to the search for the molecular determinants of lithium response and potential future research directions to pave the path towards a biomarker guided approach in lithium treatment.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

lithium
pharmacogenomics
pharmacogenetics
biomarker
personalized medicine
precision medicine
GWAS
methylation
epigenetic

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...
Pisanu, Claudia
Meloni, Anna
Severino, Giovan ...
Squassina, Aless ...
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Psykiatri
Artiklar i publikationen
International Jo ...
Av lärosätet
Uppsala universitet

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy