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Underdetection of I...
Underdetection of Interstitial Lung Disease in Juvenile Systemic Sclerosis
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- Foeldvari, Ivan (författare)
- Schon Klin Hamburg Eilbek, Hamburg Ctr Pediat & Adolescent Rheumatol, Dehnhaide 120, D-22081 Hamburg, Germany.
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- Klotsche, Jens (författare)
- German Rheumatism Res Ctr, Berlin, Germany.
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- Hinrichs, Bernd (författare)
- Asklepios Klin Nord Heidberg, Hamburg, Germany.
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- Helmus, Nicola (författare)
- Schon Klin Hamburg Eilbek, Hamburg Ctr Pediat & Adolescent Rheumatol, Dehnhaide 120, D-22081 Hamburg, Germany.
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- Kasapcopur, Ozgur (författare)
- Istanbul Univ, Cerrahpasa Med Sch, Istanbul, Turkey.
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- Adrovic, Amra (författare)
- Istanbul Univ, Cerrahpasa Med Sch, Istanbul, Turkey.
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- Sztajnbok, Flavio (författare)
- Univ Estado, Rio De Janeiro, Brazil.
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- Terreri, Maria Teresa (författare)
- Univ Fed Sao Paulo, Sao Paulo, Brazil.
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- Anton, Jordi (författare)
- Hosp St Joan Deu, Barcelona, Spain.
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- Smith, Vanessa (författare)
- Univ Ghent, Ghent Univ Hosp, Ghent, Belgium.;VIB Inflammat Res Ctr, Ghent, Belgium.
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- Katsicas, Maria (författare)
- Hosp Pediat, Buenos Aires, DF, Argentina.
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- Kostik, Mikhail (författare)
- St Petersburg State Pediat Med Univ, St Petersburg, Russia.;Almazov Natl Med Res Ctr, St Petersburg, Russia.
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- Vasquez-Canizares, Natalia (författare)
- Childrens Hosp Montefiore, Bronx, NY USA.
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- Avcin, Tadej (författare)
- Univ Med Ctr Ljubljana, Univ Childrens Hosp, Ljubljana, Slovenia.
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- Feldman, Brian (författare)
- Hosp Sick Children, SickKids, Toronto, ON, Canada.
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- Janarthanan, Mahesh (författare)
- Sri Ramachandra Univ, Chennai, Tamil Nadu, India.
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- Santos, Maria Jose (författare)
- Hosp Garcia de Orta, Almada, Portugal.
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- Sawhney, Sujata (författare)
- Sir Ganga Ram Hosp, Delhi, India.
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- Schonenberg-Meinema, Dieneke (författare)
- Univ Amsterdam, Med Ctr, Amsterdam, Netherlands.
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- Sifuentes-Giraldo, Walter-Alberto (författare)
- Univ Hosp Ramon y Cajal, Madrid, Spain.
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- Alexeeva, Ekaterina (författare)
- Sechenov First Moscow State Med Univ, Natl Med Res Ctr Childrens Hlth, Minist Hlth Russian Federat, Moscow, Russia.
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- Appenzeller, Simone (författare)
- Univ Estadual Campinas, Sao Paulo, Brazil.
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- Battagliotti, Cristina (författare)
- Hosp Ninos Dr Orlando Alassia, Santa Fe, Argentina.
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- Berntson, Lillemor, 1957- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Bica, Blanca (författare)
- Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Rio De Janeiro, Brazil.
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- Costa-Reis, Patricia (författare)
- Univ Lisbon, Hosp Santa Maria, Lisbon, Portugal.
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- Eleftheriou, Despina (författare)
- NHS Fdn Trust, Great Ormond St Hosp Children, London, England.
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- Kallinich, Tilmann (författare)
- Charite, Berlin, Germany.
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- Lehman, Thomas (författare)
- Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA.
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- Marrani, Edoardo (författare)
- Childrens Hosp, Florence, Italy.
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- Minden, Kirsten (författare)
- German Rheumatism Res Ctr, Berlin, Germany.;Charite, Berlin, Germany.
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- Nielsen, Susan (författare)
- Rigshosp, Copenhagen, Denmark.
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- Nuruzzaman, Farzana (författare)
- Stony Brook Childrens Hosp, Stony Brook, NY USA.
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- Patwardhan, Anjali (författare)
- Univ Missouri, Columbia, MO USA.
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- Khubchandani, Raju (författare)
- SRCC Childrens Hosp Mumbai, Mumbai, Maharashtra, India.
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- Stanevicha, Valda (författare)
- Riga Stradins Univ, Univ Childrens Hosp, Riga, Latvia.
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- Uziel, Yosef (författare)
- Tel Aviv Univ, Meir Med Ctr, Kefar Sava, Israel.
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- Torok, Kathryn S. (författare)
- Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA.
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Schon Klin Hamburg Eilbek, Hamburg Ctr Pediat & Adolescent Rheumatol, Dehnhaide 120, D-22081 Hamburg, Germany German Rheumatism Res Ctr, Berlin, Germany. (creator_code:org_t)
- 2022-02-17
- 2022
- Engelska.
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Ingår i: Arthritis care & research. - : John Wiley & Sons. - 2151-464X .- 2151-4658. ; 74:3, s. 364-370
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective. Utilizing data obtained from a prospective, international, juvenile systemic sclerosis (SSc) cohort, the present study was undertaken to determine if pulmonary screening with forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLco) is sufficient to assess the presence of interstitial lung disease (ILD) in comparison to high-resolution computed tomography (HRCT) in juvenile SSc. Methods. The juvenile SSc cohort database was queried for patients enrolled from January 2008 to January 2020 with recorded pulmonary function tests (PFTs) parameters and HRCT to determine the discriminatory properties of P FT parameters, FVC, and DLco in detecting ILD. Results. Eighty-six juvenile SSc patients had both computed tomography imaging and FVC values for direct comparison. Using findings on HRCT as the standard measure of ILD presence, the sensitivity of FVC in detecting ILD in juvenile SSc was only 40%, the specificity was 77%, and area under the curve (AUC) was 0.58. Fifty-eight juvenile SSc patients had both CT imaging and DLco values for comparison. The sensitivity of DLco in detecting ILD was 76%, the specificity was 70%, and AUC was 0.73. Conclusion. The performance of PFTs in juvenile SSc to detect underlying ILD was quite limited. Specifically, the FVC, which is one of the main clinical parameters in adult SSc to detect and monitor ILD, would miss -60% of children who had ILD changes on their accompanying HRCT. The DLco was more sensitive in detecting potential abnormalities on HRCT, but with less specificity than the FVC. These results support the use of HRCT in tandem with PFTs for the screening of ILD in juvenile SSc.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Foeldvari, Ivan
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Klotsche, Jens
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Hinrichs, Bernd
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Helmus, Nicola
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Kasapcopur, Ozgu ...
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Adrovic, Amra
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visa fler...
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Sztajnbok, Flavi ...
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Terreri, Maria T ...
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Anton, Jordi
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Smith, Vanessa
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Katsicas, Maria
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Kostik, Mikhail
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Vasquez-Canizare ...
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Avcin, Tadej
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Feldman, Brian
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Janarthanan, Mah ...
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Santos, Maria Jo ...
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Sawhney, Sujata
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Schonenberg-Mein ...
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Sifuentes-Girald ...
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Alexeeva, Ekater ...
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Appenzeller, Sim ...
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Battagliotti, Cr ...
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Berntson, Lillem ...
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Bica, Blanca
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Costa-Reis, Patr ...
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Eleftheriou, Des ...
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Kallinich, Tilma ...
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Lehman, Thomas
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Marrani, Edoardo
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Minden, Kirsten
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Nielsen, Susan
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Nuruzzaman, Farz ...
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Patwardhan, Anja ...
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Khubchandani, Ra ...
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Stanevicha, Vald ...
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Uziel, Yosef
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Torok, Kathryn S ...
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