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Unusual and Unexpec...
Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics
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- Konradsen, Jon R. (författare)
- Karolinska Institutet
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- Borres, Magnus P, 1956- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fisher Scientific, Immunodiagnostics, Uppsala, Sweden
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- Nilsson, Caroline (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-05-05
- 2021
- Engelska.
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Ingår i: International Archives of Allergy and Immunology. - : S. Karger. - 1018-2438 .- 1423-0097. ; 182:10, s. 904-916
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Abstract
Ämnesord
Stäng
- The fifth class of immunoglobulin, immunoglobulin E (IgE) was discovered in 1967 and has had immense importance for the understanding, diagnosis, and treatment of allergic disease. More than 50 years have passed and efforts to characterize, standardize, and refine allergens with the aim to improve clinical diagnosis and allergen-specific immunotherapy are still ongoing. Another important breakthrough was made in 1999 with the introduction of component-resolved diagnostics (CRD), making it possible to quantify IgE antibodies against individual allergen proteins for diagnostic purposes at a molecular level. The progress and developments made in allergy diagnosis often originate from clinical observations and case studies. Observant physicians and health-care personnel have reported their findings in the medical literature, which in turn has inspired researchers to become involved in clinical research. Allergists continuously encounter new allergies and are often asked by their patients how to prevent new reactions. In the current article, we focus on recent clinical observations that can now be explained by CRD. The examples taken concern allergic reactions toward peanuts, tree nuts, lemon kernels, health drinks, meat, insects, dog dander, cannabis, and semen. We now have an improved understanding of why patients may react in a serious or unexpected way, as illustrated by these examples, yet many other clinical observations remain unexplained. The aim of this review is to highlight the importance of clinical observations among allergic patients, focusing on systemic, or unusual and unexpected allergic reactions, where component-testing has further refined the diagnosis of IgE-mediated allergy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Cashew allergy
- Soy allergy
- Immunoglobulin E
- Component-resolved diagnostics
- Allergen components
- Peanut allergy
- Tree-nut allergy
- Cannabis allergy
- Crocodile allergy
- Red meat allergy
- Dog allergy
- Insect allergy
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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