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Mutations to kirrom...
Abstract
Ämnesord
Stäng
- The antibiotic kirromycin inhibits protein synthesis by binding to EF-Tu and preventing its release from the ribosome after GTP hydrolysis.We have isolated and sequenced a collection of kirromycin resistant tuf mutations and identified thirteen single amino acid substitutions at sevendifferent sites in EF-Tu. These have been mapped onto the 3D structures of EF-Tu’GTP and EF-Tu.GDP. In the active GTP form of EF-Tu themutations cluster on each side of the interface between domains I and III. We propose that this domain interface is the binding site for kirromycin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- EF-Tu
- Kirromycin
- Protein structure
- tgf mutation
- Salmonella typhimurium
- Escherichia coli
- Microbiology, immunology, infectious diseases
- Mikrobiologi, immunologi, infektionssjukdomar
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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