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Urine Hydrogen Pero...
Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury
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- Lipcsey, Miklós (författare)
- Uppsala universitet,Hedenstiernalaboratoriet
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- Bergquist, Maria (författare)
- Uppsala universitet,Klinisk fysiologi
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- Sirén, Rebecca (författare)
- Department of Medicine, Danderyd Hospital, 18288 Stockholm, Sweden.
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Huss, Fredrik, 1971- (författare)
- Uppsala universitet,Plastikkirurgi,Burn Center, Department of Plastic and Maxillofacial Surgery, Uppsala University Hospital, 75185 Uppsala, Sweden.
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- Pravda, Jay (författare)
- Inflammatory Disease Research Centre, Therashock LLC, Palm Beach Gardens, FL 33410, USA
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- Furebring, Mia (författare)
- Uppsala universitet,Infektionssjukdomar
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- Sjölin, Jan (författare)
- Uppsala universitet,Infektionssjukdomar
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- Janols, Helena (författare)
- Uppsala universitet,Infektionssjukdomar
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(creator_code:org_t)
- 2022-04-05
- 2022
- Engelska.
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Ingår i: Biomedicines. - : MDPI AG. - 2227-9059. ; 10:4
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Hydrogen peroxide (H2O2) and oxidative stress have been suggested as possible instigators of both the systemic inflammatory response and the increased vascular permeability associated with sepsis and septic shock. We measured H2O2 concentrations in the urine of 82 patients with severe infections, such as sepsis, septic shock, and infections not fulfilling sepsis-3 criteria, in patients with major burn injury with associated systemic inflammation, and healthy subjects. The mean concentrations of H2O2 were found to be lower in patients with severe infections compared to burn injury patients and healthy subjects. Patients with acute kidney injury (AKI), vs. those without AKI, in all diagnostic groups displayed higher concentrations of urine H2O2 (p < 0.001). Likewise, urine concentrations of H2O2 were higher in non-survivors as compared to survivors (p < 0.001) at day 28 in all diagnostic groups, as well as in patients with severe infections and burn injury (p < 0.001 for both). In this cohort, increased H2O2 in urine is thus associated with mortality in patients with sepsis and septic shock as well as in patients with burn injury.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- AKI
- H2O2
- TBSA
- burn injury
- hydrogen peroxide
- hypermetabolism
- mortality
- sepsis
- shock
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lipcsey, Miklós
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Bergquist, Maria
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Sirén, Rebecca
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Larsson, Anders
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Huss, Fredrik, 1 ...
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Pravda, Jay
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visa fler...
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Furebring, Mia
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Sjölin, Jan
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Janols, Helena
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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Biomedicines
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Uppsala universitet