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Placental Tissue De...
Placental Tissue Destruction and Insufficiency From COVID-19 Causes Stillbirth and Neonatal Death From Hypoxic-Ischemic Injury : A Study of 68 Cases With SARS-CoV-2 Placentitis From 12 Countries
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- Schwartz, David A. (författare)
- Perinatal Pathol, Consultat Practice, Atlanta, GA 30322 USA.,Atlanta Diabetes Associates
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- Avvad-Portari, Elyzabeth (författare)
- Fiocruz MS, Dept Pathol, Fernandes Figueira Inst, Rio De Janeiro, Brazil.,Fernandes Figueira National Institute of Health for Women, Children and Adolescents (IFF/Fiocruz)
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- Babal, Pavel (författare)
- Comenius Univ, Fac Med, Dept Pathol, Bratislava, Slovakia.,Comenius University
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- Baldewijns, Marcella (författare)
- Univ Hosp Leuven, Dept Pathol, Leuven, Belgium.,University Hospitals Leuven
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- Blomberg, Marie (författare)
- Linköping University
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- Bouachba, Amine (författare)
- Hosp Civils Lyon, Inst Pathol Multisite, Lyon, France.;SOFFOET Soc Francaise Fooetopathol, Paris, France.,Lyon Civil Hospital / Hospices Civils de Lyon
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- Camacho, Jessica (författare)
- Hosp Univ Vall dHebron, Pathol Dept, Barcelona, Spain.,Vall d'Hebron University Hospital
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- Collardeau-Frachon, Sophie (författare)
- SOFFOET Soc Francaise Fooetopathol, Paris, France.;Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Dept Pathol, Hop Femme Mere Enfant, Bron, France.,Lyon Civil Hospital / Hospices Civils de Lyon
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- Colson, Arthur (författare)
- Catholic Univ Louvain, Inst Expt & Clin Res IREC, Dept Obstet, Brussels, Belgium.,Catholic University of Louvain
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- Dehaene, Isabelle (författare)
- Ghent Univ Hosp, Dept Obstet & Gynaecol, Ghent, Belgium.,Ghent University Hospital
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- Carles Ferreres, Joan (författare)
- Parc Tauli Hosp Univ, Inst Invest & Innovacio Parc Tauli I3PT, Pathol Dept, Barcelona, Spain.;Univ Autonoma Barcelona, Sch Med, Dept Morphol Sci, Sabadell, Spain.
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- Fitzgerald, Brendan (författare)
- Cork Univ Hosp, Dept Pathol, Cork, Ireland.
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- Garrido-Pontnou, Marta (författare)
- Hosp Univ Vall dHebron, Pathol Dept, Barcelona, Spain.;Univ Autonoma Barcelona, Sch Med, Dept Morphol Sci, Barcelona, Spain.
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- Gergis, Hazem (författare)
- Doncaster & Bassetlaw NHS Teaching Hosp, Womens Hosp, Dept Obstet & Gynaecol, Doncaster, England.
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- Hargitai, Beata (författare)
- NHS Fdn Trust, Birmingham Womens & Childrens Hosp, Dept Cellular Pathol, Div Perinatal Pathol, Birmingham, W Midlands, England.
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- Cecilia Helguera-Repetto, A. (författare)
- Natl Inst Perinatol, Dept Immunobiochem, Mexico City, DF, Mexico.
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- Holmström, Sandra (författare)
- Halland Hosp, Dept Obstet & Gynaecol, Varberg, Sweden.,Hallands sjukhus, Varberg
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- Liliane Irles, Claudine (författare)
- Natl Inst Perinatol Isidro Espinosa de los Reyes, Dept Physiol & Cellular Dev, Mexico City, DF, Mexico.
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- Leijonhfvud, Åsa (författare)
- Lund Univ, Helsingborg Hosp, Dept Obstet & Gynaecol, Dept Clin Sci Helsingborg, Lund, Sweden.
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- Libbrecht, Sasha (författare)
- Antwerp Univ Hosp, Dept Pathol Anat, Edegem, Belgium.
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- Marton, Tamas (författare)
- Birmingham Womens Hosp, Cellular Pathol Dept, Birmingham, W Midlands, England.
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- McEntagart, Noel (författare)
- Rotunda Hosp, Histopathol, Dublin, Ireland.
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- Molina, James T. (författare)
- CHRISTUS Hosp St Elizabeth, Pathol & Lab Med, Beaumont, TX USA.
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- Morotti, Raffaella (författare)
- Yale Univ, Sch Med, Dept Pathol & Pediat, Autopsy Serv, New Haven, CT USA.
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- Nadal, Alfons (författare)
- Hosp Clin Barcelona, Pathol Dept, Barcelona, Spain.;Univ Barcelona, Sch Med, Dept Basic Clin Practice, Barcelona, Spain.;August Pi & Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain.
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- Navarro, Alexandra (författare)
- Hosp Univ Vall dHebron, Pathol Dept, Barcelona, Spain.
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- Nelander, Maria (författare)
- Uppsala universitet,Klinisk obstetrik
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- Oviedo, Angelica (författare)
- Burrell Coll Osteopath Med, Dept Pathol & Lab Med, Las Cruces, NM USA.
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- Oyamada Otani, Andre Ricardo (författare)
- Lab Ferdinando Costa, Sao Paulo, Brazil.
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- Papadogiannakis, Nikos (författare)
- Karolinska Inst, Dept Lab Med, Div Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden.
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- Petersen, Astrid C. (författare)
- Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark.
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- Roberts, Drucilla J. (författare)
- Harvard Med Sch, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02115 USA.
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- Saad, Ali G. (författare)
- Univ Miami, Miller Sch Med, Dept Pathol,Holtz Childrens Hosp, Pediat Pathol & Neuropathol,Jackson Hlth Syst, Miami, FL 33136 USA.
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- Sand, Anna (författare)
- Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Obstet & Gynaecol, Stockholm, Sweden.
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- Schoenmakers, Sam (författare)
- Erasmus MC Univ Med Ctr Rotterdam, Dept Obstet & Gynaecol, Rotterdam, Netherlands.
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- Sehn, Jennifer K. (författare)
- St Louis Univ, Sch Med, Dept Pathol, St Louis, MO 63104 USA.
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- Simpson, Preston R. (författare)
- CHRISTUS Hosp St Elizabeth, Dept Pathol, Beaumont, TX USA.
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- Thomas, Kristen (författare)
- NYU, Sch Med, Dept Pathol, NYU Langone Hlth Main Campus, New York, NY USA.;NYU, Sch Med, Bellevue Hosp Ctr, New York, NY USA.
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- Yolotzin Valdespino-Vazquez, M. (författare)
- Univ Hosp Leuven, Dept Pathol, Leuven, Belgium.;Natl Inst Perinatol, Dept Anat Pathol, Mexico City, DF, Mexico.
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- van der Meeren, Lotte E. (författare)
- Leiden Univ Med Ctr, Dept Pathol, Leiden, Netherlands.;Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands.
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- Van Dorpe, Jo (författare)
- Ghent Univ Hosp, Dept Pathol, Ghent, Belgium.
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- Verdijk, Robert M. (författare)
- Erasmus MC Univ Med Ctr Rotterdam, Dept Obstet & Gynaecol, Rotterdam, Netherlands.
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- Watkins, Jaclyn C. (författare)
- Harvard Med Sch, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02115 USA.
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- Zaigham, Mehreen (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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Perinatal Pathol, Consultat Practice, Atlanta, GA 30322 USA Atlanta Diabetes Associates (creator_code:org_t)
- Archives of Pathology and Laboratory Medicine, 2022
- 2022
- Engelska.
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Ingår i: Archives of Pathology & Laboratory Medicine. - : Archives of Pathology and Laboratory Medicine. - 0003-9985 .- 1543-2165. ; 146:6, s. 660-676
- Relaterad länk:
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https://doi.org/10.5...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.5...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Context: Perinatal death is an increasingly important problem as the coronavirus disease 2019 (COVID-19) pandemic continues, but the mechanism of death has been unclear.Objective: To evaluate the role of the placenta in causing stillbirth and neonatal death following maternal infection with COVID-19 and confirmed placental positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Design: Case-based retrospective clinicopathologic analysis by a multinational group of 44 perinatal specialists from 12 countries of placental and autopsy pathology findings from 64 stillborns and 4 neonatal deaths having placentas testing positive for SARS-CoV-2 following delivery to mothers with COVID-19.Results: Of the 3 findings constituting SARS-CoV-2 placentitis, all 68 placentas had increased fibrin deposition and villous trophoblast necrosis and 66 had chronic histiocytic intervillositis. Sixty-three placentas had massive perivillous fibrin deposition. Severe destructive placental disease from SARS-CoV-2 placentitis averaged 77.7% tissue involvement. Other findings included multiple intervillous thrombi (37%; 25 of 68) and chronic villitis (32%; 22 of 68). The majority (19; 63%) of the 30 autopsies revealed no significant fetal abnormalities except for intrauterine hypoxia and asphyxia. Among all 68 cases, SARS-CoV-2 was detected from a body specimen in 16 of 28 cases tested, most frequently from nasopharyngeal swabs. Four autopsied stillborns had SARS-CoV-2 identified in internal organs.Conclusions: The pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Babal, Pavel
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Blomberg, Marie
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Camacho, Jessica
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Carles Ferreres, ...
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Garrido-Pontnou, ...
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Gergis, Hazem
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Holmström, Sandr ...
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Liliane Irles, C ...
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Leijonhfvud, Åsa
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Libbrecht, Sasha
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Marton, Tamas
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McEntagart, Noel
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Molina, James T.
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Morotti, Raffael ...
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Nadal, Alfons
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Navarro, Alexand ...
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Nelander, Maria
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Oviedo, Angelica
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Oyamada Otani, A ...
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Petersen, Astrid ...
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Roberts, Drucill ...
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Saad, Ali G.
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Sand, Anna
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Sehn, Jennifer K ...
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Simpson, Preston ...
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Thomas, Kristen
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Yolotzin Valdesp ...
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Van Dorpe, Jo
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Verdijk, Robert ...
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Zaigham, Mehreen
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