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Sökning: id:"swepub:oai:DiVA.org:uu-479436" > Comparison of East‐...

Comparison of East‐Asia and West‐Europe cohorts explains disparities in survival outcomes and highlights predictive biomarkers of early gastric cancer aggressiveness

Pereira, Carla (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal;Doctoral Programme in Biomedicine Faculty of Medicine of the University of Porto Porto Portugal
Park, Ji‐Hyeon (författare)
Department of Surgery Seoul National University Hospital Seoul Republic of Korea
Campelos, Sofia (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Department of Pathology, Ipatimup Diagnostics, Institute of Molecular Pathology and Immunology University of Porto Porto Portugal
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Gullo, Irene (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Department of Pathology Centro Hospitalar Universitário de São João Porto Portugal;Faculty of Medicine of the University of Porto Porto Portugal
Lemos, Carolina (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;UniGENe, IBMC—Institute for Molecular and Cell Biology Porto Portugal;ICBAS—Instituto Ciências Biomédicas Abel Salazar Universidade do Porto Porto Portugal
Solorzano, Leslie, 1989- (författare)
Uppsala universitet,Bildanalys och människa-datorinteraktion,Science for Life Laboratory, SciLifeLab
Martins, Diana (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal;Department of Biomedical Laboratory Sciences, ESTeSC—Coimbra Health School Polytechnic Institute of Coimbra Coimbra Portugal
Gonçalves, Gilza (författare)
Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal
Leitão, Dina (författare)
Department of Pathology Centro Hospitalar Universitário de São João Porto Portugal;Faculty of Medicine of the University of Porto Porto Portugal
Lee, Hyuk‐Joon (författare)
Department of Surgery Seoul National University Hospital Seoul Republic of Korea;Cancer Research Institute Seoul National University Seoul Republic of Korea;Department of Surgery Seoul National University College of Medicine Seoul Republic of Korea
Kong, Seong‐Ho (författare)
Department of Surgery Seoul National University Hospital Seoul Republic of Korea;Department of Surgery Seoul National University College of Medicine Seoul Republic of Korea
André, Ana (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal
Borges, Clara (författare)
Medical Oncology Department Centro Hospitalar Universitário de São João Porto Portugal
Almeida, Daniela (författare)
Medical Oncology Department Centro Hospitalar Universitário de São João Porto Portugal
Wählby, Carolina, professor, 1974- (författare)
Uppsala universitet,Bildanalys och människa-datorinteraktion,Science for Life Laboratory, SciLifeLab,Avdelningen för visuell information och interaktion
Almeida, Raquel (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal;Faculty of Medicine of the University of Porto Porto Portugal;Faculty of Sciences of the University of Porto Porto Portugal
Kim, Woo Ho (författare)
Department of Pathology Seoul National University College of Medicine Seoul Republic of Korea
Carneiro, Fátima (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal;Department of Pathology Centro Hospitalar Universitário de São João Porto Portugal;Faculty of Medicine of the University of Porto Porto Portugal
Yang, Han‐Kwang (författare)
Department of Surgery Seoul National University Hospital Seoul Republic of Korea;Cancer Research Institute Seoul National University Seoul Republic of Korea;Department of Surgery Seoul National University College of Medicine Seoul Republic of Korea
Almeida, Gabriela M. (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal;Faculty of Medicine of the University of Porto Porto Portugal
Oliveira, Carla (författare)
i3S—Instituto de Investigação e Inovação em Saúde Universidade do Porto Porto Portugal;Ipatimup—Institute of Molecular Pathology and Immunology of the University of Porto Porto Portugal;Faculty of Medicine of the University of Porto Porto Portugal
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 (creator_code:org_t)
2021-12-09
2021
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 150:5, s. 868-880
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Surgical resection with lymphadenectomy and perioperative chemotherapy is the universal mainstay for curative treatment of gastric cancer (GC) patients with locoregional disease. However, GC survival remains asymmetric in West- and East-world regions. We hypothesize that this asymmetry derives from differential clinical management. Therefore, we collected chemo-naïve GC patients from Portugal and South Korea to explore specific immunophenotypic profiles related to disease aggressiveness and clinicopathological factors potentially explaining associated overall survival (OS) differences. Clinicopathological and survival data were collected from chemo-naïve surgical cohorts from Portugal (West-Europe cohort [WE-C]; n = 170) and South Korea (East-Asia cohort [EA-C]; n = 367) and correlated with immunohistochemical expression profiles of E-cadherin and CD44v6 obtained from consecutive tissue microarrays sections. Survival analysis revealed a subset of 12.4% of WE-C patients, whose tumors concomitantly express E-cadherin_abnormal and CD44v6_very high, displaying extremely poor OS, even at TNM stages I and II. These WE-C stage-I and -II patients tumors were particularly aggressive compared to all others, invading deeper into the gastric wall (P = .032) and more often permeating the vasculature (P = .018) and nerves (P = .009). A similar immunophenotypic profile was found in 11.9% of EA-C patients, but unrelated to survival. Tumours, from stage-I and -II EA-C patients, that display both biomarkers, also permeated more lymphatic vessels (P = .003), promoting lymph node (LN) metastasis (P = .019), being diagnosed on average 8 years earlier and submitted to more extensive LN dissection than WE-C. Concomitant E-cadherin_abnormal/CD44v6_very-high expression predicts aggressiveness and poor survival of stage-I and -II GC submitted to conservative lymphadenectomy.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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