SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:uu-479457"
 

Sökning: id:"swepub:oai:DiVA.org:uu-479457" > Structural and func...

Structural and functional hippocampal alterations in Multiple sclerosis and neuromyelitis optica spectrum disorder

Zheng, Fenglian (författare)
Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, 119,West Southern 4th Ring Rd, Beijing 100070, Peoples R China.
Li, Yuxin (författare)
Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai, Peoples R China.
Zhuo, Zhizheng (författare)
Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, 119,West Southern 4th Ring Rd, Beijing 100070, Peoples R China.
visa fler...
Duan, Yunyun (författare)
Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, 119,West Southern 4th Ring Rd, Beijing 100070, Peoples R China.
Cao, Guanmei (författare)
Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, 119,West Southern 4th Ring Rd, Beijing 100070, Peoples R China.
Tian, Decai (författare)
Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China.
Zhang, Xinghu (författare)
Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China.
Li, Kuncheng (författare)
Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China.
Zhou, Fuqing (författare)
Nanchang Univ, Affiliated Hosp 1, Dept Radiol, Nanchang, Jiangxi, Peoples R China.;Jiangxi Prov Med Imaging Res Inst, Neuroimaging Lab, Nanchang, Jiangxi, Peoples R China.
Huang, Muhua (författare)
Nanchang Univ, Affiliated Hosp 1, Dept Radiol, Nanchang, Jiangxi, Peoples R China.;Jiangxi Prov Med Imaging Res Inst, Neuroimaging Lab, Nanchang, Jiangxi, Peoples R China.
Li, Haiqing (författare)
Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai, Peoples R China.
Li, Yongmei (författare)
Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China.
Zeng, Chun (författare)
Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China.
Zhang, Ningnannan (författare)
Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China.;Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Gen Hosp, Tianjin, Peoples R China.
Sun, Jie (författare)
Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China.;Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Gen Hosp, Tianjin, Peoples R China.
Yu, Chunshui (författare)
Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China.;Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Gen Hosp, Tianjin, Peoples R China.
Han, Xuemei (författare)
Jilin Univ, Dept Neurol, China Japan Union Hosp, Changchun, Peoples R China.
Haller, Sven (författare)
Uppsala universitet,Radiologi,Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, 119,West Southern 4th Ring Rd, Beijing 100070, Peoples R China.;Ctr Imagerie Med Cornavin, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland.
Barkhof, Frederik (författare)
Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.;UCL, Queen Sq Inst Neurol, London, England.;UCL, Ctr Med Image Comp, London, England.
Liu, Yaou (författare)
Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, 119,West Southern 4th Ring Rd, Beijing 100070, Peoples R China.
visa färre...
Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, 119,West Southern 4th Ring Rd, Beijing 100070, Peoples R China Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai, Peoples R China. (creator_code:org_t)
2021-08-11
2022
Engelska.
Ingår i: Multiple Sclerosis Journal. - : SAGE Publications. - 1352-4585 .- 1477-0970. ; 28:5, s. 707-717
Relaterad länk:
https://discovery.uc...
visa fler...
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Hippocampal involvement may differ between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Objective: To investigate the morphometric, diffusion and functional alterations in hippocampus in MS and NMOSD and the clinical significance. Methods: A total of 752 participants including 236 MS, 236 NMOSD and 280 healthy controls (HC) were included in this retrospective multi-center study. The hippocampus and subfield volumes, fractional anisotropy (FA) and mean diffusivity (MD), amplitude of low frequency fluctuation (ALFF) and degree centrality (DC) were analyzed, and their associations with clinical variables were investigated. Results: The hippocampus showed significantly lower volume, FA and greater MD in MS compared to NMOSD and HC (p < 0.05), while no abnormal ALFF or DC was identified in any group. Hippocampal subfields were affected in both diseases, though subiculum, presubiculum and fimbria showed significantly lower volume only in MS (p < 0.05). Significant correlations between diffusion alterations, several subfield volumes and clinical variables were observed in both diseases, especially in MS (R = -0.444 to 0.498, p < 0.05). FA and MD showed fair discriminative power between MS and HC, NMOSD and HC (AUC > 0.7). Conclusions: Hippocampal atrophy and diffusion abnormalities were identified in MS and NMOSD, partly explaining how clinical disability and cognitive impairment are differentially affected.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Assessment of cognitive
Multiple sclerosis
MRI
Neuromyelitis optica spectrum disorder
Hippocampus
Hippocampal subfields

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy