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Predictors of post-...
Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging : A systematic review and meta-analysis.
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- Ball, Emily Louise (författare)
- Karolinska Institutet
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Shah, Mahnoor (författare)
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Ross, Eilidh (författare)
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Sutherland, Rachel (författare)
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Squires, Charlotte (författare)
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Mead, Gillian Elizabeth (författare)
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Wardlaw, Joanna (författare)
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Quinn, Terence Joseph (författare)
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- Religa, Dorota (författare)
- Karolinska Institutet
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- Lundström, Erik, 1964- (författare)
- Uppsala universitet,Neurologi,Stroke
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Cheyne, Joshua (författare)
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Shenkin, Susan D (författare)
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: International Journal of Stroke. - : Sage Publications. - 1747-4930 .- 1747-4949.
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Stroke survivors are at an increased risk of developing post-stroke cognitive impairment and post-stroke dementia; those at risk could be identified by brain imaging routinely performed at stroke onset.AIM: This systematic review aimed to identify features which are associated with post-stroke cognitive impairment (including dementia), on magnetic resonance imaging (MRI) performed at stroke diagnosis.SUMMARY OF REVIEW: We searched the literature from inception to January 2022 and identified 10,284 records. We included studies that performed MRI at the time of stroke (0-30 days after a stroke) and assessed cognitive outcome at least three months after stroke. We synthesised findings from 26 papers, comprising 27 stroke-populations (N=13,114, average age range=40-80 years, 19-62% female). When data were available, we pooled unadjusted (ORu) and adjusted (ORa) odds ratios.We found associations between cognitive outcomes and presence of cerebral atrophy (3 studies, N=453, ORu=2.48, 95%CI=1.15-4.62), presence of microbleeds (2 studies, N=9151, ORa=1.36, 95%CI=1.08-1.70), and increasing severity of white matter hyperintensities (3 studies, N=704, ORa=1.26, 95%CI=1.06-1.49). Increasing cerebral small vessel disease score was associated with cognitive outcome following unadjusted analysis only (2 studies, N=499, ORu=1.34, 95%CI=1.12-1.61; 3 studies, N=950, ORa=1.23, 95%CI=0.96-1.57). Associations remained after controlling for pre-stroke cognitive impairment. We did not find associations between other stroke features and cognitive outcome, or there were insufficient data.CONCLUSIONS: Acute stroke MRI features may enable healthcare professionals to identify patients at risk of post-stroke cognitive problems. However, there is still substantial uncertainty about the prognostic utility of acute MRI for this.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Cognitive impairment
- Dementia
- MRI
- Neuroimaging
- Post-stroke cognitive impairment
- Stroke
- Medicinsk vetenskap
- Medical Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ball, Emily Loui ...
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Shah, Mahnoor
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Ross, Eilidh
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Sutherland, Rach ...
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Squires, Charlot ...
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Mead, Gillian El ...
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visa fler...
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Wardlaw, Joanna
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Quinn, Terence J ...
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Religa, Dorota
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Lundström, Erik, ...
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Cheyne, Joshua
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Shenkin, Susan D
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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International Jo ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet