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The regulatory role...
The regulatory role of AP-2 beta in monoaminergic neurotransmitter systems : insights on its signalling pathway, linked disorders and theragnostic potential
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- Al-Sabri, Mohamed H. (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Nikpour, Maryam (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap,Department of Medical Sciences, Uppsala University, BMC, Husargatan 3, 750 03, Uppsala, Sweden
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- Clemensson, Laura Emily (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Attwood, Misty M. (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Williams, Michael J. (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Rask-Andersen, Mathias, 1979- (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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- Mwinyi, Jessica (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Schiöth, Helgi B. (author)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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(creator_code:org_t)
- 2022-09-08
- 2022
- English.
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In: Cell & Bioscience. - : BioMed Central (BMC). - 2045-3701. ; 12:1
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Abstract
Subject headings
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- Monoaminergic neurotransmitter systems play a central role in neuronal function and behaviour. Dysregulation of these systems gives rise to neuropsychiatric and neurodegenerative disorders with high prevalence and societal burden, collectively termed monoamine neurotransmitter disorders (MNDs). Despite extensive research, the transcriptional regulation of monoaminergic neurotransmitter systems is not fully explored. Interestingly, certain drugs that act on these systems have been shown to modulate central levels of the transcription factor AP-2 beta (AP-2 beta, gene: TFAP2B). AP-2 beta regulates multiple key genes within these systems and thereby its levels correlate with monoamine neurotransmitters measures; yet, its signalling pathways are not well understood. Moreover, although dysregulation of TFAP2B has been associated with MNDs, the underlying mechanisms for these associations remain elusive. In this context, this review addresses AP-2 beta, considering its basic structural aspects, regulation and signalling pathways in the controlling of monoaminergic neurotransmitter systems, and possible mechanisms underpinning associated MNDS. It also underscores the significance of AP-2 beta as a potential diagnostic biomarker and its potential and limitations as a therapeutic target for specific MNDs as well as possible pharmaceutical interventions for targeting it. In essence, this review emphasizes the role of AP-2 beta as a key regulator of the monoaminergic neurotransmitter systems and its importance for understanding the pathogenesis and improving the management of MNDs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Transcription factor AP-2 beta
- AP-2 beta
- TFAP2B
- Monoaminergic neurotransmitter systems
- Dopamine
- Noradrenaline
- Serotonin
- Monoamine neurotransmitter disorders
- Polymorphisms
- Obesity
- Neuroblastoma
- Diagnostic biomarker and therapeutic target
Publication and Content Type
- ref (subject category)
- for (subject category)
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