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Sökning: id:"swepub:oai:DiVA.org:uu-485919" > Factor's that impac...

Factor's that impact on women's decision-making around prenatal genomic tests : An international discrete choice survey

Buchanan, James (författare)
Univ Oxford, Hlth Econ Res Ctr, Nuffield Dept Populat Hlth, Oxford, England.;Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England.
Hill, Melissa (författare)
Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England.
Vass, Caroline M. (författare)
Univ Manchester, Manchester Ctr Hlth Econ, Manchester, Lancs, England.;RTI Hlth Solut, Manchester, Lancs, England.
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Hammond, Jennifer (författare)
Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England.
Riedijk, Sam (författare)
Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands.
Klapwijk, Jasmijn E. (författare)
Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands.
Harding, Eleanor (författare)
UCL Great Ormond St Inst Child Hlth, BSc Paediat & Child Hlth, London, England.
Lou, Stina (författare)
Aarhus Univ, Ctr Fetal Diagnost, Dept Clin Med, Aarhus, Denmark.;DEFACTUM Publ Hlth & Hlth Serv Res, Cent Denmark Reg, Aarhus, Denmark.
Vogel, Ida (författare)
Aarhus Univ, Ctr Fetal Diagnost, Dept Clin Med, Aarhus, Denmark.;Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark.
Hui, Lisa (författare)
Murdoch Childrens Res Inst, Reprod Epidemiol Grp, Parkville, Vic, Australia.;Mercy Hosp Women, Dept Perinatal Med, Heidelberg, Vic, Australia.;Northern Hlth, Dept Obstet & Gynaecol, Epping, Vic, Australia.
Ingvoldstad, Charlotta (författare)
Uppsala universitet,Centrum för forsknings- och bioetik,Karolinska Univ Hosp, Ctr Fetal Med, Stockholm, Sweden.;Karolinska Inst, Karolinska Hosp, Dept Clin Genet, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
Soller, Maria Johansson (författare)
Karolinska Inst, Karolinska Hosp, Dept Clin Genet, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
Ormond, Kelly E. (författare)
Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA.;Stanford Univ, Sch Med, Stanford Ctr Biomed Eth, Stanford, CA USA.;Swiss Fed Inst Technol, Hlth Eth & Policy Lab, Dept Hlth Sci & Technol, Zurich, Switzerland.
Choolani, Mahesh (författare)
Natl Univ Singapore Hosp, Dept Obstet & Gynaecol, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
Zheng, Qian (författare)
Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.
Chitty, Lyn S. (författare)
Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England.
Lewis, Celine (författare)
Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London, England.
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Univ Oxford, Hlth Econ Res Ctr, Nuffield Dept Populat Hlth, Oxford, England;Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England. Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England. (creator_code:org_t)
2022-04-30
2022
Engelska.
Ingår i: Prenatal Diagnosis. - : John Wiley & Sons. - 0197-3851 .- 1097-0223. ; 42:7, s. 934-946
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objective We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. Methods Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis. Results Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs. Conclusion Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

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