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Resectability, conversion, metastasectomy and outcome according to RAS and BRAF status for metastatic colorectal cancer in the prospective RAXO study

Uutela, Aki (författare)
Helsinki Univ Hosp, Abdominal Ctr, Transplantat & Liver Surg, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Österlund, Emerik (författare)
Uppsala universitet,Cancerprecisionsmedicin,Helsinki Univ Hosp, Abdominal Ctr, Transplantat & Liver Surg, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Halonen, Päivi (författare)
Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Oncol, Ctr Comprehens Canc, Helsinki, Finland.
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Kallio, Raija (författare)
Oulu Univ Hosp, Dept Oncol, Oulu, Finland.
Ålgars, Annika (författare)
Turku Univ Hosp, Dept Oncol, Turku, Finland.;Univ Turku, Turku, Finland.
Salminen, Tapio (författare)
Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Univ Tampere, Tampere, Finland.
Lamminmäki, Annamarja (författare)
Kuopio Univ Hosp, Dept Oncol, Kuopio, Finland.;Univ Eastern Finland, Kuopio, Finland.
Soveri, Leena-Maija (författare)
Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Oncol, Ctr Comprehens Canc, Helsinki, Finland.;Home Care Geriatr Clin & Palliat Care, Joint Municipal Author Hlth Care & Social Serv Ke, Hyvinkaa, Finland.
Ristamäki, Raija (författare)
Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Univ Tampere, Tampere, Finland.
Lehtomäki, Kaisa (författare)
Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Univ Tampere, Tampere, Finland.
Stedt, Hanna (författare)
Kuopio Univ Hosp, Dept Oncol, Kuopio, Finland.;Univ Eastern Finland, Kuopio, Finland.
Heervä, Eetu (författare)
Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Univ Tampere, Tampere, Finland.
Muhonen, Timo (författare)
Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Oncol, Ctr Comprehens Canc, Helsinki, Finland.;South Carelia Cent Hosp, Dept Oncol, Lappeenranta, Finland.
Kononen, Juha (författare)
Cent Finland Hosp Nova, Dept Oncol, Jyvaskyla, Finland.;Docrates Canc Ctr, Helsinki, Finland.
Nordin, Arno (författare)
Helsinki Univ Hosp, Abdominal Ctr, Transplantat & Liver Surg, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Ovissi, Ali (författare)
Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, HUS Med Imaging Ctr, Department Radiol, Helsinki, Finland.
Kytölä, Soili (författare)
Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, HUS Diagnost Ctr, HUSLAB, Dept Genet, Helsinki, Finland.
Keinänen, Mauri (författare)
Tampere Univ Hosp, Dept Genet, FIMLAB Labs, Tampere, Finland.
Sundström, Jari (författare)
Univ Turku, Turku, Finland.;Turku Univ Hosp, Dept Pathol, Turku, Finland.
Nieminen, Lasse (författare)
Univ Tampere, Tampere, Finland.;Tampere Univ Hosp, Dept Pathol, Tampere, Finland.
Mäkinen, Markus J. (författare)
Oulu Univ Hosp, Dept Pathol, Oulu, Finland.;Univ Oulu, Oulu, Finland.
Kuopio, Teijo (författare)
Univ Jyvaskyla, Dept Pathol, Cent Finland Hosp Nova, Jyvaskyla, Finland.;Univ Jyvaskyla, Dept Biol & Environm Sci, Jyvaskyla, Finland.
Ristimäki, Ari (författare)
Univ Helsinki, Helsinki, Finland.;Helsinki Univ Hosp, Dept Pathol, HUSLAB, HUS Diagnost Ctr, Helsinki, Finland.;Helsinki Univ Hosp, Appl Tumour Genom, Res Programs Unit, Helsinki, Finland.
Isoniemi, Helena (författare)
Helsinki Univ Hosp, Abdominal Ctr, Transplantat & Liver Surg, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Osterlund, Pia (författare)
Karolinska Institutet
Kytl, S (författare)
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Helsinki Univ Hosp, Abdominal Ctr, Transplantat & Liver Surg, Helsinki, Finland;Univ Helsinki, Helsinki, Finland. Cancerprecisionsmedicin (creator_code:org_t)
2022-05-24
2022
Engelska.
Ingår i: British Journal of Cancer. - : Springer Nature. - 0007-0920 .- 1532-1827. ; 127:4, s. 686-694
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background Outcomes after metastasectomy for metastatic colorectal cancer (mCRC) vary with RAS and BRAF mutational status, but their effects on resectability and conversion rates have not been extensively studied. Methods This substudy of the prospective RAXO trial included 906 patients recruited between 2011 and 2018. We evaluated repeated centralised resectability assessment, conversion/resection rates and overall survival (OS), according to RAS and BRAF status. Results Patients included 289 with RAS and BRAF wild-type (RAS and BRAFwt), 529 with RAS mutated (RASmt) and 88 with BRAF mutated (BRAFmt) mCRC. Metastatic prevalence varied between the RAS and BRAFwt/RASmt/BRAFmt groups, for liver (78%/74%/61%), lung (24%/35%/28%) and peritoneal (15%/15%/32%) metastases, respectively. Upfront resectability (32%/29%/15%), conversion (16%/13%/7%) and resection/local ablative therapy (LAT) rates (45%/37%/17%) varied for RASa and BRAFwt/RASmt/BRAFmt, respectively. Median OS for patients treated with resection/LAT (n = 342) was 83/69/30 months, with 5-year OS-rates of 67%/60%/24%, while systemic therapy-only patients (n = 564) had OS of 29/21/15 months with 5-year OS-rates of 11%/6%/2% in RAS and BRAFwt/RASmt/BRAFmt, respectively. Resection/LAT was associated with improved OS in all subgroups. Conclusions There were significant differences in resectability, conversion and resection/LAT rates according to RAS and BRAF status. OS was also significantly longer for RAS and BRAFwt versus either mutant. Patients only receiving systemic therapy had poorer long-term survival, with variation according to molecular status.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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