Tyck till om SwePub Sök
här!
Sökning: id:"swepub:oai:DiVA.org:uu-486036" >
Estimated Benefits ...
Estimated Benefits and Risks of Using a Reduced-Sodium, Potassium-Enriched Salt Substitute in India : A Modeling Study
-
- Marklund, Matti (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.;Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA
-
- Tullu, Fikru (författare)
- World Hlth Org, Country Off India, New Delhi, India.
-
- Raj Thout, Sudhir (författare)
- George Inst Global Hlth, Res & Dev Div, Hyderabad, Telangana, India.;Indian Inst Technol Hyderabad, Sangareddy, Telangana, India.
-
visa fler...
-
- Yu, Jie (författare)
- Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.;Peking Univ Third Hosp, Dept Cardiol, Beijing, Peoples R China.
-
- Brady, Tammy M. (författare)
- Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
-
- Appel, Lawrence J. (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
-
- Neal, Bruce (författare)
- Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.;Imperial Coll London, London, England.
-
- Wu, Jason H. Y. (författare)
- Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.
-
- Gupta, Rachita (författare)
- World Hlth Org, Country Off India, New Delhi, India.
-
visa färre...
-
(creator_code:org_t)
- Lippincott Williams & Wilkins, 2022
- 2022
- Engelska.
-
Ingår i: Hypertension. - : Lippincott Williams & Wilkins. - 0194-911X .- 1524-4563. ; 79:10, s. 2188-2198
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Salt substitution (ie, replacement of table and cooking salt with potassium-enriched salt substitutes) is a promising strategy to reduce blood pressure and prevent cardiovascular disease, particularly in countries like India where there is high sodium intake, mainly from discretionary salt, and low potassium intake. Life-threatening hyperkalemia from increased potassium intake is a postulated concern for individuals with chronic kidney disease.Methods: We used comparative risk assessment models to estimate the number of (1) cardiovascular deaths averted due to blood pressure reductions; (2) potential hyperkalemia-related deaths from increased potassium intake in individuals with advanced chronic kidney disease; and (3) net averted deaths from nationwide salt substitution in India. We evaluated a conservative scenario, based on a large, long-term pragmatic trial in rural China; and an optimistic scenario informed by our recent trial in India. Sensitivity analyses were conducted to assess the robustness of the findings.Results: In the conservative scenario, a nationwide salt substitution intervention was estimated to result in approximate to 214 000 (95% uncertainty interval, 92 764-353 054) averted deaths from blood pressure reduction in the total population and approximate to 52 000 (22 961-80 211) in 28 million individuals with advanced chronic kidney disease, while approximate to 22 000 (15 221-31 840) hyperkalemia-deaths might be caused by the intervention. The corresponding estimates for the optimistic scenario were approximate to 351 000 (130 470-546 255), approximate to 66 000 (24 925-105 851), and approximate to 9000 (4251-14 599). Net benefits were consistent across sensitivity analyses.Conclusions: Modeling nationwide salt substitution in India consistently estimated substantial net benefits, preventing around 8% to 14% of annual cardiovascular deaths. Even allowing for potential hyperkalemia risks there were net benefits estimated for individuals with chronic kidney disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- blood pressure
- cardiovascular diseases
- India
- potassium
- sodium
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas