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Sökning: id:"swepub:oai:DiVA.org:uu-486036" > Estimated Benefits ...

Estimated Benefits and Risks of Using a Reduced-Sodium, Potassium-Enriched Salt Substitute in India : A Modeling Study

Marklund, Matti (författare)
Uppsala universitet,Klinisk nutrition och metabolism,Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.;Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA
Tullu, Fikru (författare)
World Hlth Org, Country Off India, New Delhi, India.
Raj Thout, Sudhir (författare)
George Inst Global Hlth, Res & Dev Div, Hyderabad, Telangana, India.;Indian Inst Technol Hyderabad, Sangareddy, Telangana, India.
visa fler...
Yu, Jie (författare)
Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.;Peking Univ Third Hosp, Dept Cardiol, Beijing, Peoples R China.
Brady, Tammy M. (författare)
Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
Appel, Lawrence J. (författare)
Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.;Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
Neal, Bruce (författare)
Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.;Imperial Coll London, London, England.
Wu, Jason H. Y. (författare)
Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.
Gupta, Rachita (författare)
World Hlth Org, Country Off India, New Delhi, India.
visa färre...
 (creator_code:org_t)
Lippincott Williams & Wilkins, 2022
2022
Engelska.
Ingår i: Hypertension. - : Lippincott Williams & Wilkins. - 0194-911X .- 1524-4563. ; 79:10, s. 2188-2198
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Salt substitution (ie, replacement of table and cooking salt with potassium-enriched salt substitutes) is a promising strategy to reduce blood pressure and prevent cardiovascular disease, particularly in countries like India where there is high sodium intake, mainly from discretionary salt, and low potassium intake. Life-threatening hyperkalemia from increased potassium intake is a postulated concern for individuals with chronic kidney disease.Methods: We used comparative risk assessment models to estimate the number of (1) cardiovascular deaths averted due to blood pressure reductions; (2) potential hyperkalemia-related deaths from increased potassium intake in individuals with advanced chronic kidney disease; and (3) net averted deaths from nationwide salt substitution in India. We evaluated a conservative scenario, based on a large, long-term pragmatic trial in rural China; and an optimistic scenario informed by our recent trial in India. Sensitivity analyses were conducted to assess the robustness of the findings.Results: In the conservative scenario, a nationwide salt substitution intervention was estimated to result in approximate to 214 000 (95% uncertainty interval, 92 764-353 054) averted deaths from blood pressure reduction in the total population and approximate to 52 000 (22 961-80 211) in 28 million individuals with advanced chronic kidney disease, while approximate to 22 000 (15 221-31 840) hyperkalemia-deaths might be caused by the intervention. The corresponding estimates for the optimistic scenario were approximate to 351 000 (130 470-546 255), approximate to 66 000 (24 925-105 851), and approximate to 9000 (4251-14 599). Net benefits were consistent across sensitivity analyses.Conclusions: Modeling nationwide salt substitution in India consistently estimated substantial net benefits, preventing around 8% to 14% of annual cardiovascular deaths. Even allowing for potential hyperkalemia risks there were net benefits estimated for individuals with chronic kidney disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

blood pressure
cardiovascular diseases
India
potassium
sodium

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ref (ämneskategori)
art (ämneskategori)

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