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Is it safe to admin...
Is it safe to administer neoadjuvant chemotherapy to patients undergoing hepatectomy for intrahepatic cholangiocarcinoma? : ACS-NSQIP propensity-matched analysis
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- Choi, Woo Jin (författare)
- Univ Toronto, Dept Gen Surg, Toronto, ON, Canada.;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.
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- Ivanics, Tommy (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.;Henry Ford Hosp, Dept Surg, Detroit, MI USA.
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- Claasen, Marco P. A. W. (författare)
- Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.;Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.
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- Gallinger, Steven (författare)
- Univ Toronto, Dept Gen Surg, Toronto, ON, Canada.;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.
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- Hansen, Bettina (författare)
- Univ Hlth Network, Ctr Liver Dis, Toronto, ON, Canada.
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- Sapisochin, Gonzalo (författare)
- Univ Toronto, Dept Gen Surg, Toronto, ON, Canada.;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada.;Univ Hlth Network, Div Gen Surg, 585 Univ Ave,11PMB184, Toronto, ON M5G 2N2, Canada.
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Univ Toronto, Dept Gen Surg, Toronto, ON, Canada;Univ Hlth Network, HPB Surg Oncol, Toronto, ON, Canada. Gastrointestinalkirurgi (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: HPB. - : Elsevier. - 1365-182X .- 1477-2574. ; 24:9, s. 1535-1542
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: The use of neoadjuvant chemotherapy (NAC) in patients with intrahepatic chol-angiocarcinoma (iCCA) is increasing. The objective of this study was to compare the 30-day post-operative complications and length-of-stay (LOS) between patients undergoing hepatectomy for iCCA with and without NAC.Methods: A retrospective study was conducted using the ACS-NSQIP database queried from 2014 to 2018. Patients with NAC receipt were propensity-score matched into 1:3 ratio with controls using the greedy-matching algorithm and a caliper of 0.2. Logistic and Poisson regression models were used to estimate the effect sizes.Results: A total of 1508 patients who underwent hepatectomy for iCCA were included. 706 patients remained after matching and balance were achieved. The NAC group had 110 (60.1%) complications vs. 289 (55.3%) complications in the non-NAC group (p = 0.29). NAC was not associated with worse 30-day postoperative complications [OR 1.24, 95% CI: 0.87-1.76; p = 0.24]. Post-operative LOS in the NAC group was 8.56 days (mean, SD 7.4) vs. non-NAC group 9.27 days (mean, SD 8.41, p = 0.32). NAC was not associated with longer post-operative LOS [RR 0.93, 95% CI:0.80, 1.08; p = 0.32].Conclusion: NAC may be safely administered without increasing the risk of 30-day complications or post-operative hospital LOS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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