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Benchmarking Observ...
Benchmarking Observational Analyses Before Using Them to Address Questions Trials Do Not Answer : An Application to Coronary Thrombus Aspiration.
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- Matthews, Anthony A (författare)
- Karolinska Institutet
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Dahabreh, Issa J (författare)
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Fröbert, Ole (författare)
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- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),UCR
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- James, Stefan, 1964- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Feychting, Maria (författare)
- Karolinska Institutet
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- Jernberg, Tomas (författare)
- Karolinska Institutet
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- Berglund, Anita (författare)
- Karolinska Institutet
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Hernán, Miguel A (författare)
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(creator_code:org_t)
- 2022-05-31
- 2022
- Engelska.
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Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 191:9, s. 1652-1665
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- To increase confidence in the use of observational analyses when addressing effectiveness questions beyond those addressed by randomized trials, one can first benchmark the observational analyses against existing trial results. We used Swedish registry data to emulate a target trial similar to the Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia (TASTE) randomized trial, which found no difference in the risk of death or myocardial infarction by 1 year with or without thrombus aspiration among individuals with ST-elevation myocardial infarction. We benchmarked the emulation against the trial at 1 year and then extended the emulation's follow-up to 3 years and estimated effects in subpopulations underrepresented in the trial. As in the TASTE trial, the observational analysis found no differences in risk of outcomes by 1 year between groups (risk difference = 0.7 (confidence interval, -0.7, 2.0) and -0.2 (confidence interval, -1.3, 1.0) for death and myocardial infarction, respectively), so benchmarking was considered successful. We additionally showed no difference in risk of death or myocardial infarction by 3 years, or within subpopulations by 1 year. Benchmarking against an index trial before using observational analyses to answer questions beyond those the trial could address allowed us to explore whether the observational data can be trusted to deliver valid estimates of treatment effects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- benchmarking
- causal inference
- observational analyses
- randomized trial
- target trial emulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Matthews, Anthon ...
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Dahabreh, Issa J
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Fröbert, Ole
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Lindahl, Bertil, ...
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James, Stefan, 1 ...
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Feychting, Maria
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visa fler...
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Jernberg, Tomas
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Berglund, Anita
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Hernán, Miguel A
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet