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Fabrication of PEGy...
Fabrication of PEGylated Chitosan Nanoparticles Containing Tenofovir Alafenamide : Synthesis and Characterization
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- Zaman, Muhammad (författare)
- Univ Cent Punjab, Fac Pharm, Lahore 54000, Pakistan.
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- Hammad Butt, Muhammad (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Siddique, Waqar (författare)
- Univ South Asia USA, Dept Pharm, Lahore 54000, Pakistan.;Univ Sargodha, Coll Pharm, Sargodha 40100, Pakistan.
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- Iqbal, Muhammad Omer (författare)
- Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycoscience & Glycoengn, Qingdao 266003, Peoples R China.;Royal Inst Med Sci, Multan 59300, Pakistan.
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- Nisar, Naveed (författare)
- Inst Res & Adv Studies Pharm IRASP, Multan 59300, Pakistan.;Bahauddin Zakariya Univ Multan, Fac Pharm, Multan 59300, Pakistan.
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- Mumtaz, Asma (författare)
- Multan Med & Dent Coll, Multan 59300, Pakistan.
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- Nazeer, Hafiza Yusra (författare)
- Bahauddin Zakariya Univ Multan, Fac Pharm, Multan 59300, Pakistan.
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- Alshammari, Abdulrahman (författare)
- King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Post Box 2455, Riyadh 11451, Saudi Arabia.
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- Riaz, Muhammad Shahid (författare)
- Univ Valencia, Fac Pharm, Food Sci Toxicol & Forens Med Dept, Nutr & Food Sci Area,Prevent Med & Publ Hlth, Avda Vicent Andres Estelles S-N, Valencia 46100, Spain.
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Univ Cent Punjab, Fac Pharm, Lahore 54000, Pakistan Institutionen för läkemedelskemi (creator_code:org_t)
- 2022-12-01
- 2022
- Engelska.
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Ingår i: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 27:23
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Tenofovir alafenamide (TAF) is an antiretroviral (ARV) drug that is used for the management and prevention of human immunodeficiency virus (HIV). The clinical availability of ARV delivery systems that provide long-lasting protection against HIV transmission is lacking. There is a dire need to formulate nanocarrier systems that can help in revolutionizing the way to fight against HIV/AIDS. Here, we aimed to synthesize a polymer using chitosan and polyethylene glycol (PEG) by the PEGylation of chitosan at the hydroxyl group. After successful modification and confirmation by FTIR, XRD, and SEM, TAF-loaded PEGylated chitosan nanoparticles were prepared and analyzed for their particle size, zeta potential, morphology, crystallinity, chemical interactions, entrapment efficacy, drug loading, in vitro drug release, and release kinetic modeling. The fabricated nanoparticles were found to be in a nanosized range (219.6 nm), with similar to 90% entrapment efficacy, similar to 14% drug loading, and a spherical uniform distribution. The FTIR analysis confirmed the successful synthesis of PEGylated chitosan and nanoparticles. The in vitro analysis showed similar to 60% of the drug was released from the PEGylated polymeric reservoir system within 48 h at pH 7.4. The drug release kinetics were depicted by the Korsmeyer-Peppas release model with thermodynamically nonspontaneous drug release. Conclusively, PEGylated chitosan has the potential to deliver TAF from a nanocarrier system, and in the future, cytotoxicity and in vivo studies can be performed to further authenticate the synthesized polymer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- tenofovir alafenamide
- antiretroviral drugs
- polymer synthesis
- chitosan
- polyethylene glycol
- nanocarrier system
- nanoparticles
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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