PARP1 and Sox2 : An Unlikely Team of Pioneers to Conquer the Nucleosome.

• In this issue of Molecular Cell, Liu and Kraus (2017) demonstrate that the pioneer transcription factor Sox2 requires PARP1 to bind to a subset of its recognition motifs, which are located within nucleosomes across the genome.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

ChIP-seq

MNase-seq

PARP1

RNA-seq

Sox2

biochemistry

chromatin

nucleosome

pioneer transcription factor

Publikations- och innehållstyp

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