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Ketamine treatment ...
Ketamine treatment for refractory anxiety : A systematic review
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- Tully, Jamie L. (författare)
- Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England.
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- Dahlén, Amelia D. (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Haggarty, Connor J. (författare)
- Univ Chicago, Human Behav Pharmacol Lab, Biol Sci Div, Chicago, IL 60637 USA.
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
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- Brooks, Samantha (författare)
- Liverpool John Moores Univ, Fac Hlth, Liverpool, Merseyside, England.
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Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England Institutionen för kirurgiska vetenskaper (creator_code:org_t)
- 2022-05-20
- 2022
- Engelska.
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Ingår i: British Journal of Clinical Pharmacology. - : John Wiley & Sons. - 0306-5251 .- 1365-2125. ; 88:10, s. 4412-4426
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Ämnesord
Stäng
- There is a growing interest in the psychiatric properties of the dissociative anaesthetic ketamine, as single doses have been shown to have fast-acting mood-enhancing and anxiolytic effects, which persist for up to a week after the main psychoactive symptoms have diminished. Therefore, ketamine poses potential beneficial effects in patients with refractory anxiety disorders, where other conventional anxiolytics have been ineffective. Ketamine is a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) glutamate receptor, which underlies its induction of pain relief and anaesthesia. However, the role of NMDA receptors in anxiety reduction is still relatively unknown. To fill this paucity in the literature, this systematic review assesses the evidence that ketamine significantly reduces refractory anxiety and discusses to what extent this may be mediated by NMDA receptor antagonism and other receptors. We highlight the temporary nature of the anxiolytic effects and discuss the high discrepancy among the study designs regarding many fundamental factors such as administration routes, complementary treatments and other treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- anxiety
- anxiolytic
- depression
- ketamine
- ketamine infusion
- refractory anxiety
- treatment-resistant depression
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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