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Comparison between ...
Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in management of Graves' orbitopathy
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- Khamisi, Selwan (författare)
- Uppsala universitet,Endokrinologi och mineralmetabolism,Department of Endocrinology and Diabetes, Uppsala University Hospital, Uppsala, Sweden
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- Lundqvist, Martin (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Endocrinology and Diabetes, Uppsala University Hospital, Uppsala, Sweden
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- Edén Engström, Britt (författare)
- Uppsala universitet,Endokrinologi och mineralmetabolism,Department of Endocrinology and Diabetes, Uppsala University Hospital, Uppsala, Sweden
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Karlsson, F. Anders, 1945- (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Endocrinology and Diabetes, Uppsala University Hospital, Uppsala, Sweden
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- Ljunggren, Östen (författare)
- Uppsala universitet,Endokrinologi och mineralmetabolism,Department of Endocrinology and Diabetes, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- 2023-03-03
- 2023
- Engelska.
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Ingår i: Experimental and clinical endocrinology & diabetes. - : Georg Thieme Verlag KG. - 0947-7349 .- 1439-3646. ; 131:04, s. 236-241
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives TSH-receptor antibodies (TRAb) targeting the TSH receptor (TSH-R) induce hyperthyroidism in Graves´ disease (GD). Graves´ orbitopathy (GO) is influenced by stimulation of the TSH-R in the orbita. GO has been, among other factors, linked to high TRAb levels. Thyroid stimulating immunoglobulins (TSI) is a relatively new method for assessing TSH-receptor antibodies. The aim of this study was to investigate the role of TSI in the management of GO.Methods Patients with newly diagnosed GD (n=30, median age 55 years (range 35–72), 29 women) received pharmacological therapy (methimazole+++thyroxine) for up to 24 months. GO was identified by clinical signs and symptoms. Eleven patients had GO at diagnosis, and another six developed GO during treatment. Blood samples for TSI and other thyroidal biomarkers were obtained at baseline and on five occasions during the 24-month follow-up. Twenty-two subjects completed the drug regimen without surgery or radioiodine treatment.Results At baseline, TSI was highly correlated with TRAb (r s =0.64, p<0.001), and both assays similarly correlated to fT3 values. TSI and TRAb did not differ significantly between GO and non-GO patients for visit v1 (n=30, 17 GO during the whole study) or at follow-up (n=22, 12 GO during the whole study). During follow-up, levels of TSI and TRAb decreased and normalized in both groups.Conclusion The present study does not support any added benefit of TSI compared to TRAb for the prediction and management of GO.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Graves' disease
- TRAb
- TSI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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