Sökning: id:"swepub:oai:DiVA.org:uu-495634" >
Nanoparticles in Cl...
Nanoparticles in Clinical Trials : Analysis of Clinical Trials, FDA Approvals and Use for COVID-19 Vaccines
-
- Namiot, Eugenia D. (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
-
- Sokolov, Aleksandr V. (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
-
- Chubarev, Vladimir N. (författare)
- Ltd Liable Co LLC, Adv Mol Technol, Moscow 354340, Russia.
-
visa fler...
-
- Tarasov, Vadim V. (författare)
- Ltd Liable Co LLC, Adv Mol Technol, Moscow 354340, Russia.
-
- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi och neurovetenskap
-
visa färre...
-
(creator_code:org_t)
- 2023-01-02
- 2023
- Engelska.
-
Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 24:1
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Nanoparticles are heterologous small composites that are usually between 1 and 100 nanometers in size. They are applied in many areas of medicine with one of them being drug delivery. Nanoparticles have a number of advantages as drug carriers which include reduced toxic effects, increased bioavailability, and their ability to be modified for specific tissues or cells. Due to the exciting development of nanotechnology concomitant with advances in biotechnology and medicine, the number of clinical trials devoted to nanoparticles for drug delivery is growing rapidly. Some nanoparticles, lipid-based types, in particular, played a crucial role in the developing and manufacturing of the two COVID-19 vaccines-Pfizer and Moderna-that are now being widely used. In this analysis, we provide a quantitative survey of clinical trials using nanoparticles during the period from 2002 to 2021 as well as the recent FDA-approved drugs (since 2016). A total of 486 clinical trials were identified using the clinicaltrials.gov database. The prevailing types of nanoparticles were liposomes (44%) and protein-based formulations (26%) during this period. The most commonly investigated content of the nanoparticles were paclitaxel (23%), metals (11%), doxorubicin (9%), bupivacaine and various vaccines (both were 8%). Among the FDA-approved nanoparticle drugs, polymeric (29%), liposomal (22%) and lipid-based (21%) drugs were the most common. In this analysis, we also discuss the differential development of the diverse groups of nanoparticles and their content, as well as the underlying factors behind the trends.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- nanoparticles
- clinical trials
- liposomes
- clinicaltrials
- gov
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas